Table 6.
The prognostic value of the expression of up- and downregulated miRNAs in breast cancer patients stratified by estrogen receptor (ER) and human epidermal growth factor receptor 2 (Her2) expression status.
| miRNA | ER | Her2 | |||||||
| Positive (n = 979) | Negative (n = 283) | Positive (n = 157) | Negative (n = 1105) | ||||||
| HR 95% CI |
p Value |
HR 95% CI |
p Value |
HR 95% CI | p Value | HR 95% CI |
p Value |
||
| Upregulated | let-7b-5p | 0.72 (0.56–0.92) |
0.0083 | 1.38 (0.94–2.02) |
0.096 | 0.56 (0.35–0.91) |
0.018 | 0.75 (0.6–0.93) |
0.01 |
| miR-100-5p | 0.65 (0.52–0.8) |
0.00025 | 0.78 (0.52–1.19) |
0.25 | 0.53 (0.32–0.87) |
0.011 | 0.7 (0.57–0.88) |
0.0015 | |
| miR-140-5p | 0.66 (0.53–0.84) |
0.00048 | 0.67 (0.46–0.98) |
0.039 | 0.68 (0.4–1.14) |
0.14 | 0.67 (0.54–0.84) |
0.00043 | |
| miR-181b-5p | 1.56 (1.21–2.01) |
0.00046 | 1.45 (0.97–2.16) |
0.066 | 0.76 (0.45–1.15) |
0.16 | 1.48 (1.17–1.86) |
0.00092 | |
| miR-181c-5p | 0.57 (0.45–0.72) |
2.5 × 10−06 | 1.24 (0.85–1.82) |
0.26 | 0.68 (0.42–1.11) |
0.12 | 0.66 (0.53–0.82) |
0.00014 | |
| miR-181d-5p | 0.7 (0.55–0.88) |
0.0022 | 1.78 (1.09–2.92) |
0.02 | 0.63 (0.46–0.86) |
0.0039 | 0.77 (0.62–0.95) |
0.015 | |
| miR-199a-3p | 0.66 (0.51–0.84) |
0.00067 | 1.29 (0.85–1.94) |
0.23 | 1.3 (0.81–2.08) |
0.28 | 0.66 (0.53–0.82) |
0.00014 | |
| miR-222-3p | 1.44 (1.09–1.91) |
0.011 | 1.35 (0.93–1.96) |
0.11 | 1.55 (0.96–2.51) |
0.073 | 1.38 (1.06–1.79) |
0.016 | |
| miR-328-3p | 0.76 (0.57–1.02) |
0.065 | 0.69 (0.45–1.07) |
0.098 | 0.6 (0.37–0.98) |
0.039 | 0.8 (0.64–1.01) |
0.056 | |
| miR-495-3p | 0.66 (0.52–0.84) |
0.00079 | 0.84 (0.58–1.21) |
0.35 | 0.68 (0.42–1.09) |
0.11 | 0.66 (0.53–0.84) |
0.00043 | |
| Downregulated | miR-1-3p | 0.64 (0.49–0.85) |
0.0015 | 0.73 (0.46–1.16) |
0.18 | 0.62 (0.38–1.02) |
0.059 | 0.64 (0.49–0.83) |
0.00077 |
| miR-107 | 1.24 (0.97–1.58) |
0.091 | 0.79 (0.52–1.19) |
0.25 | 0.75 (0.47–1.22) |
0.25 | 1.22 (0.97–1.54) |
0.092 | |
| miR-129-5p | 1.45 (1.13–1.86) |
0.0037 | 0.83 (0.56–1.25) |
0.37 | 0.68 (0.41–1.14) |
0.14 | 1.36 (1.07–1.71) |
0.011 | |
| miR-141-3p | 1.53 (1.21–1.93) |
0.00029 | 1.47 (1–2.17) |
0.049 | 1.63 (0.98–2.69) |
0.055 | 1.45 (1.17–1.8) |
0.00071 | |
| miR-145-5p | 0.81 (0.63–1.03) |
0.084 | 1.15 (0.79–1.68) |
0.45 | 1.32 (0.78–2.22) |
0.3 | 0.79 (0.63–0.98) |
0.033 | |
| miR-148a-3p | 0.61 (0.48–0.78) |
4.3 × 10−05 | 1.51 (0.98–2.31) |
0.058 | 0.72 (0.43–1.2) |
0.2 | 0.65 (0.52–0.82) |
0.00028 | |
| miR-15b-5p | 1.26 (0.98–1.62) |
0.075 | 0.82 (0.54–1.24) |
0.34 | 0.64 (0.4–1.04) |
0.067 | 1.3 (1.04–1.64) |
0.024 | |
| miR-182-5p | 0.87 (0.67-1.13) |
0.31 | 1.48 (1–2.19) |
0.049 | 0.62 (0.37–0.96) |
0.033 | 0.84 (0.65–1.08) |
0.18 | |
| miR-200b-3p | 0.9 (0.71–1.13) |
0.36 | 1.72 (1.12–2.66) |
0.013 | 1.4 (0.83–2.36) |
0.2 | 1.15 (0.91–1.46) |
0.25 | |
| miR-200c-3p | 1.5 (1.18–1.9) |
0.00083 | 1.49 (1.01–2.2) |
0.045 | 1.48 (0.92–2.4) |
0.1 | 1.53 (1.21–1.92) |
0.00028 | |
| miR-203a-3p | NO DATA FOUND | ||||||||
| miR-205-5p | 0.66 (0.52–0.84) |
0.00055 | 1.4 (0.94–2.07) |
0.094 | 1.47 (0.89–2.44) |
0.13 | 0.72 (0.58–0.9) |
0.0036 | |
| miR-206-5p | 1.31 (1–1.71) |
0.051 | 1.3 (0.84–2) |
0.23 | 1.36 (0.85–2.19) |
0.2 | 1.34 (1.04–1.72) |
0.022 | |
| miR-20b-5p | 0.8 (0.61–1.05) |
0.11 | 1.17 (0.8–1.71) |
0.41 | 1.46 (0.89–2.38) |
0.13 | 1.11 (0.87–1.41) |
0.42 | |
| miR-210-3p | 1.62 (1.26–2.09) |
0.00014 | 1.97 (1.36–2.85) |
0.00025 | 1.39 (0.86–2.26) |
0.18 | 1.6 (1.26–2.02) |
9.3 × 10−05 | |
| miR-29b-3p | 0.66 (0.52–0.85) |
0.00091 | 0.63 (0.43–0.91) |
0.014 | 1.26 (0.76–2.09) |
0.37 | 0.6 (0.47–0.76) |
2.1 × 10−05 | |
| miR-485-5p | 0.62 (0.48–0.8) |
0.00015 | 1.19 (0.78–1.84) |
0.42 | 0.77 (0.47–1.28) |
0.32 | 0.61 (0.49–0.76) |
1.2 × 10−05 | |
| miR-96-5p | 0.75 (0.59–0.96) |
0.02 | 1.2 (0.79–1.81) |
0.39 | 0.6 (0.37–0.98) |
0.038 | 0.76 (0.61–0.95) |
0.018 | |
Log-rank p-values and hazard ratios (HRs; 95 % confidence interval in parentheses) are shown. Bold typing of p-values indicates a significant association (p < 0.05). Black typing is associated with better overall survival, while red typing is associated with worse overall survival. Gene chip data were used for this analysis.