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Global conformational changes in the MRN complex induced by ATP binding and hydrolysis. Cartoon representation of MRE11 (blue shades), RAD50 (red and light green), and NBS1 (orange shades). Each monomer in the MRE11 dimer is bound to a RAD50 and NBS1. ATP binding to RAD50 causes RAD50 monomers to associate creating a “closed” complex. Subsequent ATP hydrolysis and ADP + Pi release allows the complex to return to an “open” state.
