Table 1.
ZEB1 regulation by miRs in different cancers.
| MiR | Down-Stream Target | Cancer Type | Major Outcomes | Refs |
|---|---|---|---|---|
| MiR-23a | ZEB1 | Intraocular tumor | A negative feedback loop between miR-23a and ZEB1 regulates EMT and overexpression of miR-23a inhibits EMT by ZEB1 down-regulation | [248] |
| MiR-23b | ZEB1 | Bladder cancer | MiR-23b induces apoptosis and cell cycle arrest, and decreases the invasion and EMT through ZEB1 inhibition | [249] |
| MiR-33b | ZEB1 | Melanoma | Cordycepin enhances the expression of miR-33b to inhibit ZEB1 and induces mesenchymal-epithelial transition in cancer cells, resulting in decreased invasion and migration of cancer cells | [250] |
| MiR-126 | ZEB1 | Osteosarcoma | Inhibition of EMT, migration, and metastasis of cancer cells through ZEB1 down-regulation | [251] |
| MiR-128 | ZEB1 | Prostate cancer | MiR-128 sensitizes cancer cells into cisplatin chemotherapy by ZEB1 down-regulation and decreasing the malignancy and invasion of cancer cells | [252] |
| MiR-130b | ZEB1 | Endometrial cancer | The miR-130b down-regulates the expression of ZEB1 to inhibit the malignancy and invasion of cancer cells | [253] |
| MiR-139-5p | ZEB1/2 | Hepatocellular carcinoma | Reduced invasion, migration, metastasis, and EMT by ZEB1/2 down-regulation through miR-139-5p | [254] |
| Glioblastoma multiforme | Suppressing the invasion and migration of cancer cells through ZEB1/2 inhibition | [255] | ||
| MiR-141 and miR-146b-5p | AUF1/ZEB1 | Osteosarcoma | These miRs are able to down-regulate the expression of AUF1 to repress ZEB1, resulting in an increase in epithelial markers (E-cadherin and Epcam) and a decrease in mesenchymal markers (N-cadherin and Vimentin) | [256] |
|
MiR-144
MiR-144 |
ZEB1/2 | Breast cancer | MiR-144 is an onco-suppressor that inhibits EMT and migration invasion through ZEB1/2 down-regulation | [257] |
| Thyroid cancer | MiR-144 down-regulates the expression of ZEB1/2 to prevent cancer progression and proliferation | [258] | ||
| MiR-150 | ZEB1 | Esophageal squamous cell carcinoma | MiR-150 degrades ZEB1 to induce mesenchymal-epithelial transition (MET), resulting in a decrease in tumor depth, lymph node metastasis, and lymphatic invasion | [259] |
| Ovarian cancer | Suppressing the malignancy and invasion of cancer cells through ZEB1 inhibition | [260] | ||
| MiR-199a-3p | ZEB1 | Melanoma | The administration of gambogic acid is associated with up-regulation of miR-199a-3p and subsequent inhibition of ZEB1 to suppress cancer progression both in vitro and in vivo | [261] |
| MiR-199b | ZEB1 | Non-small cell lung cancer | Suppressing the proliferation, migration, and invasion of cancer cells through ZEB1 down-regulation | [262] |
| MiR-200 | ZEB1-FAK/Src | Human lung cancer | The miR-200 up-regulation decreases the invasion and malignancy of cancer cells through enhancing ZEB1 expression and subsequent activation of FAK/Src | [263] |
| ZEB1 | Endometrial carcinoma | The expression of miR-200 undergoes down-regulation in endometrial carcinoma cells to induce ZEB1 and subsequently, EMT mechanism to elevate the invasion and malignancy of cancer cells | [264] | |
| Lymphoma | Generation of a less aggressive behavior by ZEB1 inhibition through miR-200 | [265] | ||
| Insulinoma mouse model | Overexpression of miR-200 is associated with ZEB1 inhibition and decreased migration and proliferation of cancer cells | [266] | ||
| MiR-200b | ZEB1 | Osteosarcoma | Overexpression of miR-200b is associated with down-regulation of ZEB1 and decreased invasion and malignancy of cancer cells | [267] |
| Human hepatocellular carcinoma | By down-regulation of ZEB1, miR-200b reduces the stemness of cancer cells | [268] | ||
| MiR-200b and miR-141 | ZEB1 | Non-small cell lung cancer | The overexpression of miR-200b and miR-141 is related to the inhibition of ZEB1 and sensitizing cancer cells into nintedanib | [269] |
| MiR-200c | ZEB1 | Human colon cancer | Suppressing the invasion and migration of cancer cells through ZEB1 down-regulation | [270] |
| Gastric carcinoma | Overexpression of miR-200c is related to the ZEB1 down-regulation and enhanced levels of E-cadherin protein | [271] | ||
| Human bladder cancer | Administration of sulforaphane is associated with miR-200c induction and subsequently, inhibition of ZEB1 and malignancy of cancer cells | [272] | ||
| Non-small cell lung carcinoma | The cyclamen pseudibericum extract up-regulates miR-200c to induce ZEB1 down-regulation, resulting in suppressing cancer progression and proliferation | [273] | ||
| Non-small cell lung cancer | MiR-200c sensitizes cancer cells to the gefitinib-mediated apoptosis by down-regulation of ZEB1 | [274] | ||
| Lung cancer | MiR-200c sensitizes lung cancer cells into crizotinib chemotherapy by inhibition of ZEB1, and subsequently, EMT inhibition | [275] | ||
| MiR-200c and miR-141 | ZEB1 | Glioma cell | The miR-200c and -141 synergistically inhibit ZEB1 to prevent the malignancy and invasion of cancer cells | [276] |
| ZEB1/2 | Gastric cancer | MiR-200c/141 significantly decreases ZEB1/2 expression to suppress cancer malignancy | [277] | |
| MiR-203 | ZEB1 | Non-small cell lung cancer | The administration of silymarin enhances the expression of miR-203 to inhibit ZEB1 and elevate the levels of E-cadherin, resulting in suppressing cancer | [278] |
| MiR-204 | ZEB1 | Prostate cancer | MiR-204 up-regulation sensitizes cancer cells into docetaxel-mediated apoptosis through ZEB1 down-regulation | [279] |
| MiR-205 | ZEB1 | Ovarian cancer | MiR-205 enhances the invasion and migration of cancer cells via ZEB1 up-regulation. Reducing the expression of miR-205 is of interest in suppressing the malignancy of cancer cells | [280] |
| Prostate cancer | By inhibition of ZEB1, miR-205 sensitizes cancer cells into radiotherapy and induces DNA damage | [281] | ||
| Breast cancer | MiR-205 sensitizes cancer cells into radiotherapy and prevents DNA repair by ZEB1 down-regulation | [282] | ||
| MiR-205-5p | ZEB1 | Prostatic carcinoma | Suppressing the migration and invasion of cancer cells by ZEB1 down-regulation | [283] |
| MiR-340 | ZEB1/TGF-β | Breast cancer | MiR-340 inhibits ZEB1 to suppress TGF-β-mediated cancer progression | [284] |
| ZEB1 | Osteosarcoma | MiR-340 down-regulates the expression of ZEB1 to sensitize cancer cells into cisplatin-mediated apoptotic cell death | [285] | |
| MiR-409-3p | ZEB1 | Breast cancer | MiR-409-3p binds to the 3′-UTR of ZEB1 to inhibit the progression and metastasis of cancer cells | [286] |
| MiR-429 | ZEB1 | Ovarian cancer | Down-regulation of miR-429 is related to the resistance of cancer cells into cisplatin chemotherapy. Up-regulation of miR-429 suppresses ZEB1 to sensitize cancer cells into apoptosis | [287] |
| Oral squamous cell carcinoma | MiR-429 suppresses the viability and progression of cancer cells via ZEB1 down-regulation | [288] | ||
| Human thyroid cancer | MiR-429 binds to the 3′-UTR to inhibit ZEB1, resulting in suppressing invasion of cancer cells | [110] | ||
| MiR-431 | ZEB1 | Hepatocellular carcinoma | MiR-431 suppresses the migration and invasion capabilities of cancer cells through inhibition of ZEB1-mediated EMT | [289] |
| MiR-448 | ZEB1/2 | Breast cancer | The miR-448 significantly reduces the expressions of ZEB1/2 to inhibit the malignancy and invasion of cancer cells via EMT down-regulation | [290] |
| MiR-455 | ZEB1 | Non-small cell lung cancer | The miR-455 reduces the expression of ZEB1 to inhibit the malignancy of cancer cells | [291] |
| MiR-484 | Smad2/ZEB1 | Cervical cancer | Overexpression of miR-484 inhibits Smad2/ZEB1 to suppress cancer malignancy and miR-484 expression can be considered as a biomarker | [292] |
| MiR-508 | ZEB1 | Renal cell carcinoma | Up-regulation of miR-508 significantly reduces the expression of ZEB1 to inhibit EMT, leading to a decrease in cancer migration and metastasis | [293] |
| MiR-508-3p | ZEB1 | Triple negative breast cancer | Suppressing the invasion and EMT of cancer cells by down-regulation of ZEB1 | [294] |
| MiR-574-3p | ZEB1 | Human gastric carcinoma | MiR-574-3p reduces the expression of ZEB1 by binding into 3′-UTR to decrease the malignancy of cancer cells, and simultaneously, sensitize cancer cells into cisplatin therapy | [295] |
| MiR-590-3p | ZEB1/2 | Glioblastoma multiforme | Decreased invasion and migration of cancer cells by ZEB1/2 down-regulation | [296] |
| MiR-641 | ZEB1 | Cervical cancer | Negatively affecting the proliferation, migration, and invasion of cancer cells through ZEB1 down-regulation | [297] |
| MiR-652 | ZEB1 | Pancreatic cancer | Acidic microenvironment of tumor cells induces EMT through ZEB1 up-regulation. Enhancing the expression of miR-652 inhibits acidic-mediated EMT and ZEB1 induction | [298] |
| MiR-655 | TGF-β/ZEB1 | Pancreatic cancer | MiR-655 inhibits TGF-β/ZEB1 axis to suppress EMT in cancer cells | [299] |
| MiR-675-5p | UBQLN1/ZEB1/miR200 | Pancreatic cancer | The miR-675-5p reduces the malignancy of cancer cells and ZEB1 protein by up-regulation of UBQLN1 and down-regulation of miR-200 | [300] |
| MiR-873-5p | ZEB1 | Colorectal cancer | The inhibitory effect of miR-873-5p on the migration, EMT formation, and invasion of cancer cells is mediated through ZEB1 down-regulation | [301] |
| MiR-875-5p | EGFR/ZEB1 | Prostate cancer | By suppressing EGFR/ZEB1 axis, miR-875-5p inhibits EMT mechanism and sensitizes cancer cells to radiotherapy | [302] |
| MiR-1271 | ZEB1 | Pancreatic cancer | Suppressing the invasion, progression, and EMT in cancer cells by ZEB1 down-regulation | [303] |
| MiR-1236-3p | ZEB1 | High-grade serous ovarian carcinoma | There is a negative relationship between miR-1236-3p and ZEB1 to suppress the migration and invasion of cancer cells | [304] |
| MiR-1236-3p | ZEB1 | Breast cancer | ZEB1 inhibition by miR-1236-3p contributes to the inhibitory effect of this miR on the migration and invasion of cancer cells | [305] |
| MiR-3662 | ZEB1 | Melanoma | Amelioration of invasiveness and malignancy of cancer cells by ZEB1 down-regulation | [306] |