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. 2020 Jul 10;9(7):1664. doi: 10.3390/cells9071664

Figure 1.

Figure 1

The structure of High mobility group box protein 1 (HMGB1). The A- and B-box binding moieties are shown. The three cysteines determine whether HMGB1 acts as a proinflammatory mediator when outside the cell or binds to DNA when inside the nucleus. In addition, protein stability and DNA bending in vitro is determined by the C-terminal acidic tail [15]. Adapted and reproduced from Festoff, B.W.; Citron, B.A. Thrombin and the Coag-Inflammatory Nexus in neurotrauma, ALS, and other neurodegenerative disorders. Front. Neurol. 2019. doi: 10.3389/fneur.2019.00059 under the Creative Commons Attribution 4.0 license: 4.0 license: http://creativecommons.org/license/by/4.0/.