Table 2.

Overview of Stem Cell-Mediated Mitochondrial Repair for Stroke.

Experimentally Demonstrated Therapeutic Effect	Type of Stem Cell
Transfer of mitochondria via intracellular mechanisms to injured cells	MSC, iPSC, BM-MSC, EPC, ASC
Enhances astrocyte-based transfer	MSC, iPSC, BM-MSC, EPC, ASC
Represses apoptosis after IR injury	MSC
Reverses mitochondrial swelling	MSC
Diminishes mitochondrial cristae dissipation	MSC
Restores ischemic mitochondrial function	MSC
Ameliorates ganglion cell death within 14 days of stroke	MSC
Confers neuroprotection against OGD	MSC
Bolsters TNT formation after IR injury	MSC
Improves mitochondrial survival rate	hUC-MSC
Augments cell bioenergetics and locomotor function	BM-MSC
Rescues aerobic respiration in HUVECs	BM-MSC
Repairs dopaminergic neuron damage	iPSC