Figure 3.

Denguenil treatment inhibits hepatic cell necrosis and inflammation, and red blood cell (RBC) infiltration into liver. H&E staining and analysis was performed on liver smears from different groups at the 8th day and 15th day time points. Percentage necrosis, inflammation, and RBCs present in liver smear were quantified. (A) Denguenil treatment inhibited the dengue-virus-induced hepatic cell necrosis in a dose-dependent manner with the maximum protection at 15th day time point in the 140 μg/kg group. (B) Denguenil treatment inhibited the dengue virus induced liver inflammation in a dose-dependent manner. (C) RBC infiltration into liver was inhibited upon Denguenil treatment. n = 24, data are presented as means ± SEM. **, ##, #^ p < 0.001. ** Represents significant compared to Normal Control; ## Represents significant compared to their respective Disease Controls; #^ Represents significant among two time points.