Table 1.
Known cyclin dependent kinase 1 (CDK1) substrates involved in translation. CDK1 controls the phosphorylation status and activity of proteins involved in the initiation (mammalian target of rapamycin (mTOR), eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1), ribosomal protein S6 kinase B1 (p70S6K)) and elongation (eukaryotic elongation factor 2 kinase (eEF2K)) steps of mRNA translation.
| CDK1 Substrate | Ref. | Role of CDK1 Substrate | |
|---|---|---|---|
| CDK1 and mTOR | Raptor | [51] | mTOR phosphorylation and activation |
| mTOR (Ser2448) | [7] | 4E-BP1 and p70S6K phosphorylation | |
| p70S6K | [8,33] | Regulation of TOP mRNA translation | |
| LARP1 | [13,52] | Regulation of TOP mRNA translation | |
| CDK1 and 4E-BP1 | 4E-BP1 (Thr37/Thr46) |
[33] | Thr37/Thr46 phosphorylation primes 4E-BP1 for Ser65 and Thr70 phosphorylation |
| 4E-BP1 (Thr70) | [7,8] | Thr70 phosphorylation regulates 4E-BP1 | |
| 4E-BP1 (Ser83) | [8] | The role of Ser83 phosphorylation is unknown | |
| CDK1 and ribo-some assembly | eIF2α | [13] | Regulation of eIF2 complex |
| eIF4G1 | [53] | mRNA recruitment to the ribosome | |
| RPL12 | [50] | Translational program | |
| CDK1 and elongation | eEF1B | [54] | Allows ribosome movement along RNA |
| eEF1D | [55] | Delivery of aminoacyl-tRNA to the ribosome | |
| eEF2K | [56] | Regulation the elongation step of protein synthesis |