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. 2020 Jul 3;8(7):995. doi: 10.3390/microorganisms8070995

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Urobilin related pathways dysregulated in a colitis murine model induced by dextran sulfate sodium. (A) Partial least squares discriminant analysis (PLS-DA) identified L-urobilin, N, N-dimethylalanine and isocaproate as the top three important metabolites that were discriminative of the colitis phenotype. (B) Gut luminal L-urobilin concentrations were significantly reduced by DSS. (C) Isocaproate levels were significantly higher in colitis mice. NC: normal controls; MD: colitis induced by DSS; NT: DSS induced colitis mice supplemented with NT. *** p < 0.001.