Table 1.
Gut metabolites significantly affected by neoagarotetraose supplementation. P value was calculated based on Wilcoxon Rank Sum testing. Fold was defined as the ratio of mean normalized ion counts of MD to NC or NT to MD. NC: normal baseline controls; MD: colitis induced by DSS; NT: DSS induced colitis mice supplemented with neoagarotetraose.
| p Value | Fold | |||||
|---|---|---|---|---|---|---|
| Pathway | Metabolite | MD/NC | NT/MD | MD/NC | NT/MD | Category |
| Aminosugar Metabolism | fucose | 0.0213 | 0.0244 | 2.73 | 0.35 | Carbohydrate |
| Aminosugar Metabolism | N-acetylglucosamine 6-sulfate | 0.0003 | 0.0273 | 9.15 | 0.26 | Carbohydrate |
| Ascorbate and Aldarate Metabolism | gulonate | 0.0021 | 0.0413 | 60.57 | 0.06 | Cofactors and Vitamins |
| Creatine Metabolism | guanidinoacetate | 0.0585 | 0.0411 | 1.86 | 0.49 | Amino Acid |
| Dinucleotide | (3’-5’)-adenylyladenosine | 0.0000 | 0.0158 | 0.12 | 5.14 | Nucleotide |
| Fatty Acid Metabolism | butyrylglycine | 0.0178 | 0.0178 | 1.86 | 0.54 | Lipid |
| Fatty Acid, Dicarboxylate | 2-hydroxyglutarate | 0.0152 | 0.0058 | 1.81 | 0.45 | Lipid |
| Fatty Acid, Dicarboxylate | 3-hydroxyadipate | 0.0107 | 0.0270 | 0.22 | 4.19 | Lipid |
| Fatty Acid, Dicarboxylate | dodecadienoate (12:2) | 0.0003 | 0.0161 | 4.82 | 0.27 | Lipid |
| Fatty Acid, Dicarboxylate | suberate (C8-DC) | 0.0488 | 0.0307 | 0.63 | 0.59 | Lipid |
| Fatty Acid, Monohydroxy | 3-hydroxydecanoate | 0.0001 | 0.0157 | 4.68 | 0.37 | Lipid |
| Food Component/Plant | dipicolinate | 0.2604 | 0.0159 | 1.51 | 0.24 | Xenobiotics |
| Food Component/Plant | piperidine | 0.3545 | 0.0102 | 1.49 | 0.27 | Xenobiotics |
| Food Component/Plant | vanillate | 0.0069 | 0.0082 | 1.43 | 0.71 | Xenobiotics |
| Galactosyl Glycerolipids | 1-palmitoyl-galactosylglycerol (16:0) | 0.0116 | 0.0012 | 0.47 | 3.02 | Lipid |
| Glutamate Metabolism | S-1-pyrroline-5-carboxylate | 0.0009 | 0.0462 | 2.88 | 0.53 | Amino Acid |
| Glutamate Metabolism | succinylglutamine | 0.0002 | 0.0181 | 24.30 | 0.18 | Amino Acid |
| Glycine, Serine and Threonine Metabolism | N-acetylserine | 0.0001 | 0.0291 | 3.82 | 0.40 | Amino Acid |
| Histidine Metabolism | cis-urocanate | 0.1436 | 0.0074 | 1.65 | 2.16 | Amino Acid |
| Long Chain Monounsaturated Fatty Acid | erucate (22:1n9) | 0.8395 | 0.0335 | 1.01 | 1.90 | Lipid |
| Lysine Metabolism | N-acetyl-cadaverine | 0.1339 | 0.0025 | 2.06 | 2.12 | Amino Acid |
| Lysophospholipid | 1-oleoyl-GPG (18:1) | 0.0119 | 0.0449 | 3.92 | 2.51 | Lipid |
| Medium Chain Fatty Acid | caprylate (8:0) | 0.0750 | 0.0156 | 1.52 | 0.54 | Lipid |
| Medium Chain Fatty Acid | cis-4-decenoate (10:1n6) | 0.0049 | 0.0224 | 4.09 | 0.30 | Lipid |
| Medium Chain Fatty Acid | heptanoate (7:0) | 0.0017 | 0.0379 | 2.53 | 0.43 | Lipid |
| Nicotinate and Nicotinamide Metabolism | nicotinamide riboside | 0.7553 | 0.0289 | 1.44 | 2.42 | Cofactors and Vitamins |
| Phosphatidylethanolamine (PE) | 1-oleoyl-2-linoleoyl-GPE (18:1/18:2) | 0.0309 | 0.0467 | 4.58 | 0.21 | Lipid |
| Phosphatidylethanolamine (PE) | 1-palmitoyl-2-linoleoyl-GPE (16:0/18:2) | 0.0011 | 0.0456 | 2.89 | 0.52 | Lipid |
| Phospholipid Metabolism | glycerophosphoserine | 0.0000 | 0.0441 | 19.33 | 0.25 | Lipid |
| Purine, (Hypo)Xanthine/Inosine containing | 2’-deoxyinosine | 0.0022 | 0.0051 | 0.34 | 3.57 | Nucleotide |
| Purine Metabolism, Guanine containing | 2’-deoxyguanosine | 0.0025 | 0.0068 | 0.28 | 5.09 | Nucleotide |
| Pyrimidine Metabolism, Uracil containing | beta-alanine | 0.1512 | 0.0282 | 1.95 | 0.37 | Nucleotide |
| Sterol | campesterol | 0.3166 | 0.0169 | 0.91 | 1.38 | Lipid |
| Sterol | stigmastadienone | 0.0133 | 0.0001 | 0.87 | 1.34 | Lipid |
| TCA Cycle | 2-methylcitrate/homocitrate | 0.0751 | 0.0447 | 1.59 | 0.55 | Energy |
| Tocopherol Metabolism | delta-tocopherol | 0.0021 | 0.0307 | 1.61 | 1.45 | Cofactors and Vitamins |
| Tryptophan Metabolism | indole-3-carboxylate | 0.0458 | 0.0145 | 1.68 | 0.52 | Amino Acid |