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. 2020 Jul 8;12(7):738. doi: 10.3390/v12070738

Figure 3.

Figure 3

Representation of the 3D structure of the HBc–NTD dimer. Two orthogonal views of the HBc dimer are shown. This dimer structure was obtained from the Protein Data Bank (PDB) 1QGT [24]. Each monomer is formed of five α-helices. Helices 3 (red) and 4 (blue) display a hairpin shape assembling into a four-helical bundle within the dimer, generating the capsid spikes of the particle. The spike tip (in green) corresponds to the highly immunogenic c/e1 epitope [23]. The fifth helix (magenta) and the downstream proline-rich loop are involved in the dimer–dimer oligomerization.