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. 2020 Jul 9;59(6):2819–2820. doi: 10.1007/s00394-020-02286-1

Correction to: Low-phytate wholegrain bread instead of high-phytate wholegrain bread in a total diet context did not improve iron status of healthy Swedish females: a 12 week, randomized, parallel-design intervention study

Michael Hoppe 1,2,, Alastair B Ross 3, Cecilia Svelander 3, Ann‑Sofie Sandberg 3, Lena Hulthén 2
PMCID: PMC7413893  PMID: 32648019

Correction to: European Journal of Nutrition (2019) 58:853–864 https://doi.org/10.1007/s00394-018-1722-1

Due to author error the paper was published with a statistical fault.

The “Results” section in the abstract should read: “Fifty-five females completed the study. There was a significant difference in change over time in total body iron stores between the two groups (p < 0.035). In the low-phytate bread group (n = 24) there were significant within-group decreases in both ferritin (mean 12%; from 32 ± 7 to 27 ± 6 μg/L, geometric mean ± SEM, p < 0.018) and total body iron (mean 12%; from 6.9 ± 1.4 to 5.4 ± 1.1 mg/kg, p < 0.035). Plasma alkylresorcinols indicated that most subjects complied with the intervention”.

The first sentence in the “Conclusions” section in the abstract should read: “In Swedish females of reproductive age, no statistically significant difference in iron status was detected after 12 weeks of high-phytate wholegrain bread consumption”.

The “Post-intervention iron status” Result section should read: “Following 12 weeks of intervention there was a significant difference in change over time in total body iron stores between the two groups (p < 0.035, Table 1). Within the low-phytate bread group there were a decrease in S-ferritin (p < 0.018) and amount of body iron reserves (p < 0.035).”

Table 1.

Data at baseline and after 12 weeks of intervention

High-phytate bread group (n = 31) Low-phytate bread group (n = 24) p value (between groups)
Baseline Post-intervention p value (within group) Baseline Post-intervention p value (within group)
BMI (kg/m2) 22.6 ± 0.6 22.8 ± 0.6 0.326 21.7 ± 0.5 21.8 ± 0.5 0.145 0.774
Hb (g/L) 134 ± 1 136 ± 1 0.155 132 ± 1 134 ± 1 0.178 0.682
Hepcidin (ng/mL) 11.8 ± 2.4 11.8 ± 2.0 0.704 13.6 ± 2.7 9.5 ± 2.8 0.433 0.343
Ferritin (µg/L) 31 ± 4 32 ± 4 0.859 33 ± 3 27 ± 6 0.018 0.251
TfR (mg/L) 2.7 ± 0.1 2.7 ± 0.1 0.409 2.9 ± 0.1 2.9 ± 0.6 0.489 0.491
Body Fea (mg/kg) 7.0 ± 0.4 7.0 ± 0.5 0.738 6.9 ± 0.4 5.4 ± 0.5 0.035 0.035
Alkyl-resorcinols (mmol/L) 351 ± 52 467 ± 77 0.120 266 ± 68 522 ± 127 0.002 0.139
C17:C21 ratio 0.16 ± 0.02 0.23 ± 0.02 0.018 0.15 ± 0.02 0.29 ± 0.03 0.001 0.051

Subjects were allocated into two groups that either received (on a daily basis) 200 g wholegrain rye flour-based bread natural high in phytates or 200 g dephytinized wholegrain rye flour-based bread. Evaluation was done at baseline and after 12 weeks

Values represent geometric mean ± standard error of the mean (SEM, as italicized values)

Bold values indicate the level of significance p ≤ 0.05

aCalculation of body iron reserves was based on the ratio between soluble transferrin receptor and serum ferritin [27]

Also, Table 1 and 2 should state the actual p values, and not just NS (not significant). Thus, revised tables are provided. Accordingly, the p value for change over time in dietary phytate-P intake for the high-phytate bread group in Fig. 2 should state “p = 0.106”.

Table 2.

Whole grain intake at baseline and after 12 weeks of intervention

High-phytate bread group (n = 31) Low-phytate bread group (n = 24) p value (between groups)
Baseline During intervention p value3 (within group) Baseline During intervention p value (within group)
Total WG intake (g/day) 75 ± 47 111 ± 27 0.010 81 ± 51 112 ± 35 0.076 0.696
WG intake in connection with main meals (g/day) 69 ± 43 90 ± 34 0.046 76 ± 49 93 ± 41 0.263 0.622
WG intake when excluding WG from bread (g/day) 42 ± 28 31 ± 28 0.014 43 ± 39 34 ± 34 0.003 0.350
WG intake from total dietary bread (g/day) 27 ± 25 76 ± 6 0.001 30 ± 23 76 ± 6 0.001 0.760
WG intake from bread alone in connection with main meals (g/day) 23 ± 21 55 ± 19 0.001 24 ± 23 55 ± 18 0.001 0.629

Data are presented as geometric mean ± standard error of the mean (SEM, as italicized values)

Bold values indicate the level of significance p ≤ 0.05


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