Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Structural superposition of the Cdk4 structure in complex with Hsp90 and Cdc37 in the original Cryo-EM structure (5FWK) with the structure of the Abl kinase (yellow). For clarity only Hsp90 (gray surface) and Cdk4 (blue) are displayed. The Cdk4 is superimposed to Abl (yellow) by overlapping the C-lobe. The red van der Waals spheres represent the predicted Hsp90 binding region, which appears to optimally trace the surface of Hsp90 and overlap with the unfolding part of Cdk4.
