Table 1. Effects of various doses of HESS, GB and GB plus HESS on lipid profile in experimental groups .
Groups | Parameters | |||||
BS (mg/dL) | Cholesterol (mg/dL) | TG (mg/dL) | HDL-C (mg/dL) | LDL-C(mg/dL) | VLDL-C (mg/dL) | |
NCa | 90.6±5b-e | 86.92±2.9b-h | 64.01±4.5b-h | 42.02±1.83b-e | 35.93±2.07b-d | 12.80±0.90b-h |
DCb | 324.6±14a,c-h | 231.70±8.8a,f-h | 93.35±5.7a,f-h | 28.86±0.54a,d-h | 51.80±1.39a,f-h | 18.67±1.15a,f-h |
HESS-100c | 221.4±13a,b,d-h | 231.52±7.8a,f-h | 94.25±4.7a,f-h | 29.49±2.81a,e-h | 51.77±2.54a,f-h | 18.85±0.95a,f-h |
HESS-200d | 170.3±27-a-c,f-h | 218.66±10.6a,f-h | 87.67±3.0a,g,h | 34.21±2.69a,b,f-h | 45.97±4.39a,g,h | 17.53±0.61a,g,h |
HESS-400e | 159.4±33-a-c,f-h | 218.37±12.9a,f-h | 86.51±2.4a,h | 35.47±2.40-a-c,h | 45.05±4.25a,h | 17.30±0.48a,h |
GBf | 105.4±8b-e | 111.78±7.4a-e | 80.60±2.9a-c | 40.45±3.38b-d | 42.10±4.29b,c | 16.1±0.59a-c |
GB+HESS-200g | 99.3±5b-e | 105.30±7.5a-e | 78.97±0.9a-d | 40.95±3.20b-d | 38.49±3. 41b-d | 15.78±0.20a-d |
GB+HESS-400h | 99.8±2b-e | 106.28±8.0a-e | 78.36±1.27a-e | 41.58±2.58b-e | 37.81±2.31b-e | 15.67±0.25a-e |
ANOVA ( P value) | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 |
The variables are presented as means ± SD. NC (normal control); DC (Diabetic control); HESS (hydroalcoholic extract of S. securidaca seeds); GB (glibenclamide).Groups at the left column have been defined by superscript letters (a–h). Superscript letters (a–f) within a column denote significant differences ( P < 0.05).