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. 2020 Apr 30;45(10):1645–1655. doi: 10.1038/s41386-020-0682-3

Fig. 2. Central nesfatin-1 reduces motivation to work for sucrose in a high-effort condition.

Fig. 2

Effects of i.c.v. administration of nesfatin-1 on the number of lever presses (a), breakpoint (b), rewards earned (c) and home cage chow food intake (d) in ad libitum fed mice in the progressive ratio schedule of reinforcement (N = 6). Effects of VTA-specific administration of nesfatin-1 on the number of lever presses (e), breakpoint (f), rewards earned (g) and home cage chow food intake (H) in ad libitum fed mice (N = 8) in the progressive ratio schedule of reinforcement. Operant behavioral sessions were performed at the beginning of the dark phase, began 30 min after drug administration and lasted 1 h. Data represent mean ± SEM. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. PBS group (Dunnett´s post hoc test or paired Student’s t test).