TABLE A1.
The relative abundances of 129 pathways were significantly changed in OE individuals compared with the NW groups
| Pathway |
NW relative frequency (%) mean ± SD |
OW relative frequency (%) mean ± SD |
p‐Values |
|---|---|---|---|
| PWY‐5971 | 0.1931 ± 0.1349 | 0.2708 ± 0.1734 | 5.45E−11 |
| PENTOSE‐P‐PWY | 0.4021 ± 0.1285 | 0.3532 ± 0.1140 | 4.87E−08 |
| FASYN‐INITIAL‐PWY | 0.1628 ± 0.1234 | 0.2150 ± 0.1393 | 1.23E−07 |
| PWY‐7664 | 0.2106 ± 0.1528 | 0.2746 ± 0.1695 | 1.24E−07 |
| GLCMANNANAUT‐PWY | 0.2290 ± 0.0710 | 0.2037 ± 0.0604 | 1.62E−07 |
| PWYG‐321 | 0.2146 ± 0.1528 | 0.2771 ± 0.1663 | 1.64E−07 |
| PWY‐6282 | 0.1902 ± 0.1449 | 0.2501 ± 0.1612 | 1.85E−07 |
| PWY‐5989 | 0.1918 ± 0.1481 | 0.2520 ± 0.1639 | 2.57E−07 |
| POLYAMINSYN3‐PWY | 0.0616 ± 0.0379 | 0.0759 ± 0.0372 | 3.11E−07 |
| PWY0‐862 | 0.1926 ± 0.1447 | 0.2505 ± 0.1594 | 3.67E−07 |
| PWY‐5505 | 0.5451 ± 0.1688 | 0.6013 ± 0.1448 | 1.11E−06 |
| PWY‐7007 | 0.0008 ± 0.0063 | 0.0035 ± 0.0079 | 1.13E−06 |
| PWY‐5484 | 0.6491 ± 0.1140 | 0.6094 ± 0.1114 | 1.98E−06 |
| GLUCARGALACTSUPER‐PWY | 0.0222 ± 0.0255 | 0.0149 ± 0.0179 | 4.96E−06 |
| GALACTARDEG‐PWY | 0.0222 ± 0.0255 | 0.0149 ± 0.0179 | 4.96E−06 |
| PWY‐6071 | 0.0035 ± 0.0105 | 0.0077 ± 0.0138 | 5.75E−06 |
| REDCITCYC | 0.1191 ± 0.1076 | 0.0889 ± 0.0776 | 9.24E−06 |
| PWY‐7332 | 0.0137 ± 0.0213 | 0.0083 ± 0.0128 | 1.67E−05 |
| GLYCOLYSIS | 0.7464 ± 0.0847 | 0.7200 ± 0.0824 | 1.90E−05 |
| PWY‐6901 | 0.4311 ± 0.1174 | 0.3968 ± 0.1061 | 3.05E−05 |
| PWY‐7446 | 0.0082 ± 0.0151 | 0.0045 ± 0.0098 | 3.95E−05 |
| PWY‐7220 | 0.6884 ± 0.1044 | 0.6587 ± 0.0970 | 6.21E−05 |
| PWY‐7222 | 0.6884 ± 0.1044 | 0.6587 ± 0.0970 | 6.21E−05 |
| METHGLYUT‐PWY | 0.0120 ± 0.0211 | 0.0069 ± 0.0141 | 6.84E−05 |
| PWY‐6519 | 0.2150 ± 0.1206 | 0.2500 ± 0.1223 | 9.87E−05 |
| P108‐PWY | 0.4574 ± 0.1624 | 0.4143 ± 0.1473 | 0.0002 |
| PWY‐5676 | 0.1208 ± 0.0744 | 0.1039 ± 0.0573 | 0.0005 |
| PWY‐5180 | 0.0253 ± 0.0326 | 0.0178 ± 0.0260 | 0.0005 |
| PWY‐5182 | 0.0253 ± 0.0326 | 0.0178 ± 0.0260 | 0.0005 |
| GLUCUROCAT‐PWY | 0.2137 ± 0.0745 | 0.2324 ± 0.0707 | 0.0005 |
| PWY‐6471 | 0.1483 ± 0.1003 | 0.1240 ± 0.0903 | 0.0005 |
| PWY0‐41 | 0.0124 ± 0.0189 | 0.0085 ± 0.0122 | 0.0006 |
| GLUCARDEG‐PWY | 0.0246 ± 0.0256 | 0.0189 ± 0.0192 | 0.0006 |
| BIOTIN‐BIOSYNTHESIS‐PWY | 0.2195 ± 0.1112 | 0.2471 ± 0.1076 | 0.0006 |
| TCA | 0.5675 ± 0.1223 | 0.5385 ± 0.1119 | 0.0007 |
| PWY‐6478 | 0.0414 ± 0.0411 | 0.0517 ± 0.0422 | 0.0008 |
| PWY‐7090 | 0.0022 ± 0.0032 | 0.0016 ± 0.0018 | 0.0008 |
| GALACT‐GLUCUROCAT‐PWY | 0.2319 ± 0.0727 | 0.2490 ± 0.0679 | 0.0009 |
| PWY‐5022 | 0.0369 ± 0.0366 | 0.0292 ± 0.0276 | 0.0010 |
| PWY‐6690 | 0.0101 ± 0.0171 | 0.0067 ± 0.0118 | 0.0013 |
| HCAMHPDEG‐PWY | 0.0101 ± 0.0171 | 0.0067 ± 0.0118 | 0.0013 |
| PWY0‐321 | 0.0051 ± 0.0157 | 0.0090 ± 0.0175 | 0.0014 |
| PYRIDNUCSAL‐PWY | 0.6468 ± 0.0809 | 0.6636 ± 0.0631 | 0.0014 |
| PWY‐7254 | 0.0876 ± 0.0899 | 0.0694 ± 0.0668 | 0.0015 |
| GLYOXYLATE‐BYPASS | 0.0492 ± 0.0623 | 0.0369 ± 0.0434 | 0.0015 |
| PWY‐5677 | 0.0271 ± 0.0244 | 0.0225 ± 0.0166 | 0.0024 |
| PWY‐7663 | 0.9422 ± 0.0817 | 0.9574 ± 0.0553 | 0.0025 |
| PWY‐6588 | 0.1974 ± 0.1010 | 0.1774 ± 0.0814 | 0.0027 |
| RIBOSYN2‐PWY | 0.6539 ± 0.0671 | 0.6670 ± 0.0524 | 0.0027 |
| KETOGLUCONMET‐PWY | 0.0134 ± 0.0231 | 0.0090 ± 0.0166 | 0.0028 |
| P42‐PWY | 0.7444 ± 0.1884 | 0.7062 ± 0.1643 | 0.0031 |
| PWY0‐1533 | 0.0230 ± 0.0272 | 0.0178 ± 0.0211 | 0.0032 |
| PWY0‐1296 | 0.4445 ± 0.1115 | 0.4673 ± 0.0999 | 0.0032 |
| ANAEROFRUCAT‐PWY | 0.6227 ± 0.0880 | 0.6047 ± 0.0804 | 0.0034 |
| PWY‐6969 | 0.6513 ± 0.1314 | 0.6249 ± 0.1149 | 0.0035 |
| PWY‐6126 | 0.7834 ± 0.0636 | 0.7700 ± 0.0612 | 0.0036 |
| PWY‐5913 | 0.4997 ± 0.1519 | 0.4689 ± 0.1391 | 0.0040 |
| PWY‐7228 | 0.4718 ± 0.1020 | 0.4510 ± 0.0956 | 0.0042 |
| P341‐PWY | 0.0014 ± 0.0052 | 0.0006 ± 0.0025 | 0.0051 |
| PWY‐7197 | 0.3681 ± 0.0967 | 0.3488 ± 0.0916 | 0.0052 |
| PWY‐6125 | 0.5017 ± 0.0964 | 0.4826 ± 0.0911 | 0.0054 |
| PWY‐5747 | 0.0136 ± 0.0187 | 0.0103 ± 0.0137 | 0.0060 |
| PWY‐5667 | 0.8401 ± 0.0899 | 0.8569 ± 0.0787 | 0.0065 |
| PWY0‐1319 | 0.8401 ± 0.0899 | 0.8569 ± 0.0787 | 0.0065 |
| P122‐PWY | 0.1046 ± 0.0615 | 0.0939 ± 0.0459 | 0.0065 |
| PWY‐5705 | 0.0176 ± 0.0170 | 0.0146 ± 0.0129 | 0.0069 |
| PWY‐5154 | 0.3929 ± 0.1133 | 0.3715 ± 0.1030 | 0.0070 |
| GLYCOCAT‐PWY | 0.8738 ± 0.1187 | 0.8961 ± 0.1077 | 0.0074 |
| PWY‐841 | 0.5890 ± 0.0899 | 0.5716 ± 0.0869 | 0.0074 |
| PWY‐7200 | 0.3806 ± 0.0613 | 0.3691 ± 0.0566 | 0.0075 |
| PWY‐6163 | 0.7938 ± 0.0703 | 0.8064 ± 0.0595 | 0.0077 |
| PWY‐5347 | 0.3726 ± 0.1086 | 0.3926 ± 0.0957 | 0.0078 |
| PWY‐621 | 0.5584 ± 0.1486 | 0.5841 ± 0.1179 | 0.0083 |
| PWY0‐42 | 0.0110 ± 0.0177 | 0.0082 ± 0.0117 | 0.0083 |
| PWY0‐1277 | 0.0164 ± 0.0261 | 0.0119 ± 0.0199 | 0.0083 |
| PWY‐7184 | 0.3518 ± 0.0778 | 0.3376 ± 0.0701 | 0.0088 |
| PWY0‐845 | 0.2685 ± 0.1161 | 0.2478 ± 0.1005 | 0.0092 |
| PWY‐5973 | 0.8943 ± 0.0760 | 0.9063 ± 0.0516 | 0.0099 |
| GLYCOGENSYNTH‐PWY | 0.8051 ± 0.1419 | 0.8306 ± 0.1305 | 0.0109 |
| TCA‐GLYOX‐BYPASS | 0.0564 ± 0.0703 | 0.0451 ± 0.0517 | 0.0112 |
| PWY‐5532 | 0.0010 ± 0.0020 | 0.0007 ± 0.0012 | 0.0114 |
| GOLPDLCAT‐PWY | 0.0068 ± 0.0127 | 0.0094 ± 0.0152 | 0.0125 |
| PYRIDOXSYN‐PWY | 0.2254 ± 0.1127 | 0.2057 ± 0.1032 | 0.0129 |
| DENOVOPURINE2‐PWY | 0.5938 ± 0.0826 | 0.5789 ± 0.0821 | 0.0137 |
| PWY‐7237 | 0.0543 ± 0.0561 | 0.0630 ± 0.0411 | 0.0144 |
| PWY‐4984 | 0.1049 ± 0.0787 | 0.0935 ± 0.0530 | 0.0178 |
| PWY‐6165 | 0.0016 ± 0.0035 | 0.0025 ± 0.0058 | 0.0204 |
| PWY‐7196 | 0.5429 ± 0.1101 | 0.5243 ± 0.1087 | 0.0214 |
| ARO‐PWY | 0.7795 ± 0.0856 | 0.7929 ± 0.0745 | 0.0214 |
| FAO‐PWY | 0.0545 ± 0.0568 | 0.0460 ± 0.0451 | 0.0223 |
| PHOSLIPSYN‐PWY | 0.7803 ± 0.0894 | 0.7941 ± 0.0763 | 0.0223 |
| PWY0‐166 | 0.4147 ± 0.0681 | 0.4042 ± 0.0579 | 0.0225 |
| P164‐PWY | 0.1413 ± 0.0669 | 0.1315 ± 0.0506 | 0.0225 |
| PWY‐7199 | 0.5239 ± 0.0738 | 0.5119 ± 0.0700 | 0.0227 |
| PWY0‐781 | 0.2635 ± 0.0963 | 0.2488 ± 0.0801 | 0.0228 |
| PWY‐5659 | 0.5976 ± 0.0871 | 0.5835 ± 0.0816 | 0.0232 |
| CODH‐PWY | 0.0179 ± 0.0216 | 0.0213 ± 0.0190 | 0.0234 |
| P124‐PWY | 0.1339 ± 0.0888 | 0.1210 ± 0.0676 | 0.0238 |
| GLYCOL‐GLYOXDEG‐PWY | 0.0291 ± 0.0321 | 0.0245 ± 0.0239 | 0.0245 |
| PWY‐5415 | 0.0065 ± 0.0148 | 0.0045 ± 0.0104 | 0.0254 |
| PWY0‐162 | 0.5985 ± 0.0980 | 0.5828 ± 0.0940 | 0.0255 |
| RUMP‐PWY | 0.0667 ± 0.0562 | 0.0588 ± 0.0413 | 0.0267 |
| PWY‐5304 | 0.1095 ± 0.0954 | 0.1243 ± 0.0881 | 0.0276 |
| COMPLETE‐ARO‐PWY | 0.8166 ± 0.0871 | 0.8297 ± 0.0758 | 0.0278 |
| HISTSYN‐PWY | 0.7138 ± 0.0779 | 0.7017 ± 0.0732 | 0.0290 |
| PWY‐7187 | 0.4234 ± 0.0635 | 0.4139 ± 0.0558 | 0.0299 |
| P163‐PWY | 0.0352 ± 0.0357 | 0.0303 ± 0.0257 | 0.0301 |
| PWY‐6185 | 0.0024 ± 0.0074 | 0.0038 ± 0.0095 | 0.0301 |
| PWY‐5910 | 0.0185 ± 0.0400 | 0.0131 ± 0.0289 | 0.0303 |
| PWY‐6151 | 0.4874 ± 0.1112 | 0.5037 ± 0.0971 | 0.0319 |
| SER‐GLYSYN‐PWY | 0.7444 ± 0.0713 | 0.7552 ± 0.0664 | 0.0328 |
| PWY‐922 | 0.0135 ± 0.0309 | 0.0095 ± 0.0217 | 0.0334 |
| PWY‐5695 | 0.6651 ± 0.1110 | 0.6481 ± 0.1065 | 0.0338 |
| PWY‐7013 | 0.0434 ± 0.0496 | 0.0369 ± 0.0356 | 0.0354 |
| PWY‐6608 | 0.2527 ± 0.1048 | 0.2378 ± 0.0902 | 0.0365 |
| PWY‐6470 | 0.0213 ± 0.0356 | 0.0165 ± 0.0271 | 0.0380 |
| PWY‐6182 | 0.0024 ± 0.0074 | 0.0037 ± 0.0093 | 0.0381 |
| PWY‐5198 | 0.0005 ± 0.0018 | 0.0013 ± 0.0068 | 0.0387 |
| GLUCOSE1PMETAB‐PWY | 0.0470 ± 0.0659 | 0.0393 ± 0.0342 | 0.0389 |
| ARGSYNBSUB‐PWY | 0.6160 ± 0.1288 | 0.6344 ± 0.1157 | 0.0399 |
| TEICHOICACID‐PWY | 0.0879 ± 0.0496 | 0.0950 ± 0.0452 | 0.0412 |
| GLYCOLYSIS‐TCA‐GLYOX‐BYPASS | 0.0819 ± 0.0870 | 0.0706 ± 0.0667 | 0.0441 |
| CATECHOL‐ORTHO‐CLEAVAGE‐PWY | 0.0025 ± 0.0069 | 0.0038 ± 0.0105 | 0.0449 |
| PWY‐3781 | 0.1989 ± 0.1952 | 0.1734 ± 0.1545 | 0.0452 |
| THREOCAT‐PWY | 0.0054 ± 0.0166 | 0.0080 ± 0.0182 | 0.0458 |
| PWY‐5417 | 0.0027 ± 0.0076 | 0.0041 ± 0.0111 | 0.0468 |
| PWY‐5431 | 0.0027 ± 0.0076 | 0.0041 ± 0.0111 | 0.0468 |
| PWY‐7560 | 0.7715 ± 0.0707 | 0.7811 ± 0.0632 | 0.0497 |
| NONMEVIPP‐PWY | 0.7715 ± 0.0707 | 0.7811 ± 0.0632 | 0.0497 |