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成年大鼠与老年大鼠在不同给药速率下ECS结构与功能参数比较

Comparison of structural and functional parameters of ECS between adult rats and aged rats at different drug delivery rates

Items	0.1 μL/min	0.2 μL/min	0.3 μL/min
Volume fraction, x±s
Adult rats	17.20%±0.03%	17.60%±0.04%	18.20%±0.05%
Aged rats	18.20%±0.04%	17.70%±0.03%	17.20%±0.03%
P	0.004	0.261	0.045
Degree of tortuosity, x±s
Adult rats	1.78±0.09	1.77±0.07	1.76±0.10
Aged rats	1.63±0.04	1.69±0.06	1.79±0.11
P	0.004	0.135	0.896
Diffusion coefficient/(×10-4 mm2/s), x±s
Adult rats	3.36±0.37	3.42±0.37	3.40±0.43
Aged rats	3.99±0.21	3.70±0.26	3.31±0.55
P	0.004	0.155	0.723
Clearance rate/(×10-4 mm2/s), x±s
Adult rats	3.25±0.43	3.37±0.72	3.26±0.55
Aged rats	1.94±0.68	2.53±0.45	4.04±0.76
P	0.003	0.021	0.014
Half-life/min, x±s
Adult rats	81.12±5.12	81.89±3.81	86.51±3.35
Aged rats	141.83±7.25	105.95±8.67	88.61±3.71
P	0.002	0.154	0.328