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Farnesene favors high-sensitivity nAChRs in neuro-2a cells. A, α4β2 nAChRs assemble in two stoichiometries, and we observed that farnesene treatment shifts a mixed population of HS and LS α4β2 nAChRs to a majority of HS α4β2 nAChRs. B, In examining α4α6β2 nAChRs, under control treatments, ∼65% of the population are α4α6β2 nAChRs while the remainder is likely α4β2 nAChRs. Following treatment with farnesene, <14% of the nAChRs are α4α6β2 nAChRs.
