Table 1.
Analytical data for the synthesized compounds.
| No | Compound | Formula | ESI-MS [M + H] + m/z | tR [min] | LogP | |
|---|---|---|---|---|---|---|
| Calcd | Obsvd | |||||
| 1a [33] | H-Tyr-D-Ala-Gly-Phe-NH-N=CH-3,5-(CF3)2Ph | C32H32F6N6O5 | 695.24 | 694.95 | 12.91 | 5.55 |
| 1b | H-Tyr-D-Ala-Gly-Phe-NH-NH-C(=O)-3,5-(CF3)2Ph | C32H32F6N6O6 | 711.24 | 710.85 | 11.82 | 4.5 |
| 1c | H-Tyr-D-Ala-Gly-Phe-NH-NH-C(=O)-CH2-3,5-(CF3)2Ph | C33H34F6N6O6 | 725.25 | 724.90 | 12.10 | 3.54 |
| 1d | H-Tyr-D-Ala-Gly-Phe-NH-NH-C(=O)-NH-N=CH-3,5-(CF3)2Ph | C33H34F6N8O6 | 753.26 | 752.85 | 12.53 | 4.19 |
| 2a | H-Tyr-D-Ala-Gly-Trp-NH-N=CH-3,5-(CF3)2Ph | C34H33F6N7O5 | 734.25 | 733.90 | 12.88 | 5.48 |
| 2b | H-Tyr-D-Ala-Gly-Trp-NH-NH-C(=O)-3,5-(CF3)2Ph | C34H33F6N7O6 | 750.25 | 749.95 | 12.03 | 4.43 |
| 3a | H-Tyr-D-Ala-Phe-Phe-NH-N=CH-3,5-(CF3)2Ph | C39H38F6N6O5 | 785.29 | 784.85 | 14.20 | 7.74 |
| 3b | H-Tyr-D-Ala-Phe-Phe-NH-NH-C(=O)-3,5-(CF3)2Ph | C39H38F6N6O6 | 801.28 | 800.85 | 13.40 | 6.69 |
| 4a | H-Tyr-D-Ala-Trp-NH-N=CH-3,5-(CF3)2Ph | C32H30F6N6O4 | 677.23 | 677.15 | 12.94 | 6.09 |
| 4b | H-Tyr-D-Ala-Trp-NH-NH-C(=O)-3,5-(CF3)2Ph | C32H30F6N6O5 | 693.23 | 692.85 | 12.25 | 5.04 |
| 5a | H-Tyr-Pro-Phe-Phe-NH-N=CH-3,5-(CF3)2Ph | C41H40F6N6O5 | 811.30 | 810.80 | 14.09 | 8.03 |
| 6a | H-Tyr-Pro-Phe-NH-N=CH-3,5-(CF3)2Ph | C32H31F6N5O4 | 664.24 | 664.16 | 13.25 | 6.03 |