FIG 2.

Downstream targets of ATR transcriptional regulation in HPV-positive CIN612 cells. (a) The heat map of genes of the immune response system process pathway in the scrambled (TRC) and ATR knockdown (shATR) cells with or without differentiation (72 h). (b) Heat maps of highly differentially expressed genes modulated by ATR knockdown. (c) RT-PCR analysis of IFN-β, IFN-κ, CXCL2, CXCL10, IL-6, and IL-18 in CIN612 cells with ATR knockdown. (d) RT-PCR analysis of STAT-1, PKR, IFIT1, and HMGB1 in CIN612 cells with ATR knockdown. GAPDH was used as an internal control and for normalization of the data. Data are means ± standard errors (error bars). P value <0.05. All results are representative of observations from two or more independent experiments.