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Cytotoxic response of knockout mutant cell lines to specific oxidative stress inducers. WT and knockout mutant monoclonal HAP1 cell lines were treated with (A) 350 μM H2O2 or (B) 375 μM paraquat and assessed for cell survival using trypan blue after 3 days of treatment. Error bars represent SEM (n = 6 independent experiments). *, P < 0.05; **, P < 0.005; ****, P < 0.0001 (compared to WT cells).
