In the original article, there were six minor mistakes in Table 1 as published.
Table 1.
Intrinsic factors and glial-derived extrinsic signals influencing cell decisions in Drosophila and mammalian neurogenic niches.
| Names/symbols | Human orthologs | Gene groups and pathways | Description |
|---|---|---|---|
| In Drosophila: | |||
| Intrinsic factors | |||
| Abdominal A (abd-A) | HOXA6 | Bithorax complex | Required for segmental identity of the second through eighth abdominal segments |
| HOXC6 | HOX-like homeobox TFs | ||
| Abdominal B (Abd-B) | HOXA11 | Bithorax complex | Specifies the identity of the posterior abdominal segments |
| HOXD11 | HOX-like homeobox TFs | ||
| Antennapedia (Antp) | HOXB7 | Antennapedia complex | Regulates segmental identity in the mesothorax |
| HOX-like homeobox TFs | |||
| Asense (ase) | ASCL1 | Basic helix-loop-helix TFs | tTF in d-IPC Type I Nbs |
| ACSL2 | |||
| Atonal (ato) | ATOH7 | Basic helix-loop-helix TFs | tTF in d-IPC Type I and III Nbs |
| Baboon (babo) | TGFβR1 | TGF-β type I receptors | Required for proliferation of Nbs |
| Broad (br) | BTBD18 | C2H2 zinc finger TFs | tTF in thoracic later-born neurons |
| Castor (cas) | CASZ1 | C2H2 zinc finger TFs | tTF in VNC Type I Nbs, thoracic Type I Nbs, CB Type II Nbs and INPs |
| Chronologically inappropriate morphogenesis (Chinmo) | BTBD18 | C2H2 zinc finger TFs | tTF in thoracic early-born neurons |
| Dachshund (dac) | DACH1 | Other DNA binding domain TFs | tTF in d-IPC Type I Nbs |
| Decapentaplegic (dpp) | BMP2 | Bone morphogenetic proteins signaling pathway core components | Patterns the dorsal surface of the embryo and is expressed in a subset of Rx+ tOPC NECs |
| Deformed (Dfd) | HOXC4 | Antennapedia complex | Involved in proper morphological identity of the maxillary segment and the posterior half of the mandibular segment |
| HOX-like homeobox TFs | |||
| Dichaete (D) | SOX12 | High mobility group box TFs | tTF in Me, tOPC and d-IPC Type I Nbs, CB Type II Nbs and INPs |
| SOX14 | |||
| SOX21 | |||
| Distal-less (Dll) | DLX1 | NK-like homeobox TFs | Expressed in Wg+ tOPC NECs and tTF in tOPC Type 0 Nbs |
| DLX6 | |||
| Dorsal (dl) | RELA | Nuclear factor-κB | Patterns the ventral side of the embryo |
| RELB | |||
| Drop (Dr) | MSX2 | NK-like homeobox TFs | Specifies the dorsal portion of the neuroectoderm |
| Engrailed (en) | EN1 | NK-like homeobox TFs | Segment polarity gene involved in compartment identity and boundary formation |
| Epidermal growth factor receptor (EGFR) | EGFR | Receptor tyrosine kinases | Required for expansion of OPC NECs and patterns the ventral side of the embryo |
| Eyeless (ey) | PAX6 | Paired homeobox TFs | tTF in Me and tOPC Type I Nbs, CB Type II Nbs and INPs |
| Grainy head (grh) | GRHL1 | Polycomb group recruiters/DNA-binding proteins | tTF in CB Type II Nbs and INPs |
| Gooseberry (gsb) | PAX3 | Paired homeobox TFs | Expressed in segmentally repeating pattern to define the A/P polarity of embryonic segments |
| Hedgehog (hh) | SHH | Hedgehog signaling pathway core component | Marks ventral half of the OPC NECs |
| DHH | |||
| Homothorax (hth) | MEIS1 | Tale homeobox TFs | tTF in Me Type I Nbs |
| MEIS2 | |||
| Hunchback (hb) | IKZF5 | C2H2 zinc finger TFs | tTF in VNC Type I Nbs |
| IGF-II mRNA-binding protein (Imp) | IGF2BP1 | mRNA-binding protein | tTF in thoracic early-born neurons |
| IGF2BP2 | |||
| IGF2BP3 | |||
| Intermediate neuroblasts defective (ind) | GSX1 | HOX-like homeobox TFs | Specifies the intermediate portion of the neuroectoderm |
| Klumpfuss (Klu) | ZBTB7A | C2H2 zinc finger TFs | tTF in Me Type I Nbs |
| Kruppel (Kr) | BCL6 | C2H2 zinc finger TFs | tTF in VNC Type I Nbs |
| Labial (lab) | HOXA1 | Antennapedia complex | Specifies derivatives of gnathocephalic segments |
| HOXB1 | HOX-like homeobox TFs | ||
| Optix | SIX3 | Six/Sine oculis homeobox TFs | Marks the adjacent ventral and dorsal main regions to Vsx1+ OPC NECs |
| SIX6 | |||
| Retinal Homeobox (Rx) | RAX | Paired-like homeobox TFs | Marks the tOPC NECs |
| POU domain protein 2 (Pdm2) | POU2F3 | POU homeobox TFs | tTF in VNC Type I Nbs |
| Proboscipedia (pb) | HOXA2 | Antennapedia complex | Required for the formation of labial and maxillary palps |
| HOXB2 | HOX-like homeobox TFs | ||
| Seven up (svp) | NR2F2 | Nuclear receptor TFs | tTF in CB Type II Nbs and INPs |
| Sex combs reduced (Scr) | HOXA5 | Antennapedia complex | Required for labial and first thoracic segment development |
| HOX-like homeobox TFs | |||
| Sloppy paired 1 (slp 1) | FOXG1 | Fork head box TFs | tTF in Me and tOPC Type I Nbs |
| Syncrip (Syp) | HNRNPR | mRNA-binding protein | tTF in thoracic later-born neurons |
| SYNCRIP | |||
| Tailless (tll) | NR2E1 | Nuclear receptor TFs | tTF in Me Type I Nbs |
| Ultrabithorax (Ubx) | HOXB6 | Bithorax complex | Controls development of the posterior thoracic and first abdominal segments |
| HOX-like homeobox TFs | |||
| Ventral nervous system defective (vnd) | NKX2-2 | NK-like homeobox TFs | Specifies the ventral portion of the neuroectoderm |
| Visual system homeobox 1 (Vsx1) | VSX2 | Paired-like homeobox TFs | Expressed in central OPC NECs |
| Wingless (wg) | WNT1 | Wnt-TCF signaling pathway core component | Segment polarity gene involved in controlling the segmentation pattern of embryos by affecting the posterior cells of each parasegment and is expressed in a second subset of Rx+ tOPC NECs |
| Niche/glia-derived factors | INHBA | TGFβ superfamily ligand | Secreted from surface glia |
| Activin-β (Actβ) | INHBB | ||
| Anachronism (ana) | – | Glycoprotein | Secreted from cortex glia |
| Dally-like (dlp) | GPC4 | Heparan sulfate proteoglycan Glypican (Membrane tethered) | Secreted from surface glia |
| Drosophila insulin-like peptides 1–8s (dILP1–8s) | IGF1/2 | Insulin-like peptides | Secreted from cortex and surface glia |
| Glass bottom boat (gbb) | BMP7 | Bone morphogenetic proteins signaling pathway ligand | Secreted from surface glia |
| Jelly belly (jeb) | – | Ligand of anaplastic lymphoma kinase | Secreted from glia |
| Spitz (Spi) | TGF-α | EGFR signaling pathway ligand | Secreted from cortex glia |
| Terribly reduced optic lobes (trol) | HSPG2 | Heparan sulfate proteoglycan Perlecan (ECM component) | Secreted from surface glia |
| Symbols/names | Drosophila orthologs | Gene groups and pathways | Description |
| In mammals: | |||
| Intrinsic factors | |||
| Castor zinc finger 1 (CasZ1) | Cas | C2H2 zinc finger TFs | tTF in the specification of late-born cell types in the retina |
| COUP-TF interacting protein 2/B cell leukemia/lymphoma 11B (Citp2/BCL11B) | CG9650 | C2H2 zinc finger TFs | Specification of Layer V neurons |
| Distal-less homeobox 2 (Dlx2) | Dll | NK-like homeobox TFs | Regional specification (embryonic subpallium (LGE and MGE) and lateral postnatal/adult SEZ) |
| Empty spiracles homeobox 1 (Emx1) | ems | NK-like homeobox TFs | Regional specification (embryonic pallium and dorsal postnatal/adult SEZ) |
| Empty Spiracles Homeobox 2 (Emx2) | ems | NK-like homeobox TFs | Dentate gyrus regional identity |
| Eomesodermin (Tbr2) | Doc1 | T-Box TFs | Specification of INPs |
| Eukaryotic translation initiation factor 4E nuclear import factor 1 (4E-T/EIF4ENIF1) | 4E-T | eIF4E/mRNA translation regulator | Translational repression of neuronal specification TFs |
| Fez family zinc finger 2 (Fezf2) | erm | C2H2 zinc finger TFs | Specification of Layer V neurons |
| Forkhead box G1 (Foxg1) | Slp2 | Fork head box TFs | Specification of deep-layer neurons |
| GS homeobox 2 (Gsh2/Gsx2) | ind | HOX-like homeobox TFs | Regional specification (embryonic subpallium (LGE and MGE) and dorsolateral postnatal/adult SEZ) |
| HOP homeobox (Hopx) | – | Homeobox TFs | Dentate gyrus regional identity |
| IKAROS family zinc finger 1 (Ikzf1) | Hb | C2H2 Zinc finger TFs | tTF in the specification of early-born cell types in the cortex and retina |
| Lysine (K)-specific methyltransferase 2A (Mll1/ KMT2B) | trx | Trithorax complex | Preservation of regional identity |
| Lymphoid enhancer binding factor 1 (Lef1) | pan | High mobility group box TFs | Dentate gyrus regional identity |
| Neurogenic differentiation 1 (Neurod1) | amos | Proneural basic helix-loop-helix TFs | Required for neuronal differentiation |
| ato | |||
| Neurogenin 2 (Neurog2) | tap | Proneural basic helix-loop-helix TFs | Drives differentiation of NSCs into neurons |
| NK2 homeobox 1 (Nkx2-1) | scro | NK-like homeobox TFs | Regional specification (embryonic subpallium (MGE), and ventrolateral and medial postnatal/adult SEZ) |
| Nuclear receptor subfamily 2, group F, member 1 (Nr2f1/COUP-TFI) | svp | Nuclear receptor TFs | Specification of upper-layer neurons |
| Paired box 6 (Pax6) | ey | Paired homeobox TFs | Expressed in Radial glia/NSCs; regional specification (embryonic pallium, dorsal postnatal/adult SEZ) |
| POU domain, class 3, transcription factor 3 (Brn1/POU3F3) | vvl | POU homeobox TFs | Specification of upper-layer neurons |
| Pumilio RNA-binding family member 2 (Pum2) | pum | RNA-binding family | Translational repression of neuronal specification TFs |
| Special AT-rich sequence binding protein 2 (Satb2) | dve | CUT homeobox TFs | Specification of upper-layer neurons |
| SRY (sex determining region Y)-box 5 (Sox5) | Sox102F | High mobility group box TFs | Specification of layer VI neurons |
| T-box brain transcription factor 1 (Tbr1) | Doc1 | T-Box TFs | Specification of layer VI neurons |
| Transducin-like enhancer of split 4 (Tle4) | gro | Transcriptional corepressor | Specification of deep-layer neurons |
| Zinc finger E-box binding homeobox 2 (Sip1/Zeb2) | zfh1 | C2H2 zinc finger TFs | Feedback signaling from neurons to progenitors |
| Zinc finger protein of the cerebellum 1 (Zic1) | opa | C2H2 zinc finger TFs | Regional specification (embryonic medial subpallium and septal postnatal/adult SEZ) |
| Niche/Astroglia-derived factors | |||
| Insulin-like growth factor binding protein 6 (IGFBP6) | – | Regulation of insulin-like growth factor receptor signaling pathway | Secreted by non-neurogenic astroglia |
| Insulin-like growth factor 1 (Igf1) | dilp2 | Insulin-like growth factor ligand | Systemic/niche factor |
| Interleukin 1 beta (IL-1β) | – | Cytokine activity | Secreted by SGZ niche astroglia |
| interleukin 6 (IL-6) | – | Cytokine activity | Secreted by SGZ niche astroglia |
| Jagged 1 (Jag1) | Ser | Notch signaling pathway membrane-bound ligand | Expressed by forebrain astroglia |
| Neurogenesin-1/Chordin-like protein 1 (Ng1/Chrdl1) | – | BMP antagonist | Secreted by SGZ niche astroglia |
| Secreted frizzled-related protein 4 (sFRP4) | – | Wnt antagonist | Secreted by OB astroglia |
| Thrombospondin 1 (Thbs1) | Tsp | Glycoprotein (ECM component) | Secreted by forebrain astroglia |
| Wingless-type MMTV integration site family (Wnt3,Wnt7a) | wg | Wnt pathway ligand | Secreted by SGZ/SEZ niche astroglia |
CB, central brain; d-IPC, distal inner proliferation center; ECM, extracellular matrix; LGE, lateral ganglionic eminence; Me, medulla; MGE, medial ganglionic eminence; Nbs, neuroblasts; NECs, neuroepithelial cells; NSCs, neural stem cells; OB, olfactory bulb; SEZ, subependymal zone; SGZ, subgranular zone; TFs, transcription factors; tTF, temporal transcription factor; t-OPC, tip of the outer proliferation center; VNC, ventral nerve cord.
The gene group for Eyeless (ey) was stated as Paired is homeobox TFs.
The gene group for Gooseberry (gsb) was stated as Paired is homeobox TFs.
The gene group for Homothorax (hth) was stated as Tale is homeobox TFs.
The gene group for Optix was stated as Six/Sine oculis is homeobox TFs.
The gene group for Retinal Homeobox (Rx) was stated as Paired-like is homeobox TFs.
The gene group for Visual system homeobox 1 (Vsx1) was stated as Paired-like is homeobox TFs.
The correct gene groups are as follows:
The correct gene group for Eyeless (ey) is Paired homeobox TFs.
The correct gene group for Gooseberry (gsb) is Paired homeobox TFs.
The correct gene group for Homothorax (hth) is Tale homeobox TFs.
The correct gene group for Optix is Six/Sine oculis homeobox TFs.
The correct gene group for Retinal Homeobox (Rx) is Paired-like homeobox TFs.
The correct gene group for Visual system homeobox 1 (Vsx1) is Paired-like homeobox TFs.
The corrected Table 1 appears below.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.