. 2020 Jul 23;21(12):841–851. doi: 10.2217/pgs-2020-0053

Table 2. . All variants included in genetic analysis.

Gene	rs ID	Chromosomal position	Reference allele	Variant type	Reason for variant inclusion (candidate SNV, tag SNV, missense or functional)	Corresponding genetic predictor^†
ARHGEF10	rs9657362	8:1833801	G	Missense	Candidate, missense	1, 2
	rs17683288	8:1877480	T	Missense	Candidate, missense	1, 2
	rs141069028	8:1851564	C	Missense	Missense	2
	rs2294039	8:1857591	G	Missense	Missense	2
	rs201516531	8:1905361	C	Missense	Missense	2
	rs887797448	8:1900880	G	Missense	Missense	2
	rs139515492	8:1905048	C	Missense	Missense	2
SBF2	rs117957652	11:9861208	C	Missense	Candidate	3
	rs7102464	11:9879838	T	Missense	Candidate	3
	rs59613534	11:9800552	C	3 prime UTR	Functional (CADD: 19.22, GWAVA: 0.71)	4
	rs60154961	11:9800566	G	3 prime UTR	Functional (CADD: 18.12, GWAVA: 0.67)	4
	rs360126	11:9800346	G	3 prime UTR	Functional (CADD: 17.02, GWAVA: 0.68)	4
	rs360125	11:9800650	G	3 prime UTR	Functional (CADD: 17.01, GWAVA: 0.63)	4
	rs1045634	11:9800450	T	3 prime UTR	Functional (CADD: 15.01, GWAVA: 0.70)	4
	rs146366305	11:9989990	A	Missense	Functional (CADD: 25.3, PROVEAN: -2.53	4
FGD4	rs10844253	12:32764184	A	Synonymous	Tag SNV of rs10771973 (r² = 0.92)	5
	rs11539445	12:32908237	A	Regulatory	Functional (CADD: 24.2, GWAVA: 0.50, GTEx p = 0.00012)	6
	rs10844308	12:32854366	C	Regulatory	Functional (CADD: 17.03, GWAVA: 0.54, GTEx p = 0.00012)	Excluded due to LD^‡
FZD3	rs7833751	8:28362792	G	Intron	Tag SNV of rs7001034 (r² = 0.98)	7
NXN	rs11247571	17:908502	G	Regulatory	Functional (CADD: 17.79, GWAVA: 0.51, GTEx p = 0.0000049)	8

^{^†}

Corresponding genetic predictor: the genetic predictor (Table 3) in which each SNV was included.

^{^‡}

Variant excluded from analysis due to LD with rs11539445 (r² = 0.93).

CADD: Combined annotation-dependent depletion; LD: Linkage disequilibrium.