1Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, 114 Taiwan
2Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, 114 Taiwan
3Department of Oral and Maxillofacial Surgery, Changhua Christian Hospital, Changhua, 500 Taiwan
4College of Nursing and Health Science, Da-Yeh University, Chang-hua, 515 Taiwan
5Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, 114 Taiwan
6Department of Dentistry, Tri-Service General Hospital, National Defense Medical Center, No. 161, Sec. 6, Min‑Chuan East Rd., Nei‑Hu, Taipei, 114 Taiwan
7Molecular and Cell Biology, Taiwan International Graduate Program, Academia Sinica and Graduate Institute of Life Science, National Defense Medical Center, Taipei, 114 Taiwan
8Department of Internal Medicine, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
9Department of Oral and Maxillofacial Surgery, Chi Mei Medical Center, Tainan, 710 Taiwan
10Department and Graduate Institute of Biochemistry, National Defense Medical Center, Taipei, 114 Taiwan
© The Author(s) 2020
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.