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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Peptides. 2020 Jul 13;131:170369. doi: 10.1016/j.peptides.2020.170369

Figure 17. Amphipathic Glycopeptides Based DAMGO and DTLET.

Figure 17.

Highly amphipathic glycopeptides related to DAMGO and DTLET were synthesized and studied for their in vivo antinociception. These glycopeptides contained various flexible and rigid linkers separating the message and address segments. As seen with the previous study on amphipathic β-endorphin glycopeptides, the un-glycosylated analogues did not perform as well as their glycosylated counterparts. (Polt 2015) [91].