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. 2020 Jun 30;161(1):53–65. doi: 10.1111/imm.13224

Figure 3.

Figure 3

V(D)J pairing of variable regions of the heavy chain of heavy‐chain‐only antibodies (VHHs) is biased. (a) VJ pairing of germline genes in the naive VHH repertoire is highly biased to pairs of certain germline genes. The top 21 VJ pair made up >90% of the clones in the repertoire. (b, c) In silico simulation of DJ and VJ combination. The error bars illustrate the relative deviation of the 2000 steps of simulation, while the columns represent the relative deviation of the VHHs repertoire.