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. 2020 Jul 31;23(9):101426. doi: 10.1016/j.isci.2020.101426

Figure 6.

Figure 6

Vitamin B1 Inhibition Induces Excessive Maturation of γδ Thymocytes through TGF-β Superfamily Signaling in Fetal Thymic Organ Cultures

FACS plot of CD24– TCRγδ+ cells among DN developing thymocytes from sorted DN1–3 cells reconstituted in fetal thymic organ cultures incubated in the presence of oxythiamine, the TGF-β superfamily inhibitor K02288, or both agents. Horizontal lines indicate median values. p values were obtained by using the Mann-Whitney U-test (∗∗∗p < 0.001, ∗∗p < 0.01). The data shown are pooled from three independent experiments, which yielded reproducible data.