Table 2.
Characteristics of included studies or consortia of inflammatory diseases, cardiovascular diseases, and cancers.
| Outcome | Source | Cases | Controls | Sample size | Population |
| Inflammatory disease | |||||
| Rheumatoid arthritis | GARNET consortium | 29 880 | 73 758 | 103 638 | Mix |
| Inflammatory bowel disease | UK IBD consortium | 25 042* | 34 915 | 59 957 | European |
| Cardiovascular disease | |||||
| Cerebrovascular disease | |||||
| Overall stroke | MEGASTROKE consortium | 67 162 | 454 450 | 521 612 | Mix |
| Overall stroke | UKBB | 9652 | 357 991 | 367 643 | European |
| Any ischaemic stroke | MEGASTROKE consortium | 60 341 | NA | NA | Mix |
| Any ischaemic stroke | UKBB | 3554 | 364 089 | 367 643 | European |
| Large artery stroke | MEGASTROKE consortium | 6688 | 146 392 | 153 080 | Mix |
| Small vessel stroke | MEGASTROKE consortium | 11 710 | 192 662 | 204 372 | Mix |
| Cardioembolic stroke | MEGASTROKE consortium | 9006 | 204 570 | 213 576 | Mix |
| Intracerebral haemorrhage | UKBB | 1064 | 366 579 | 367 643 | European |
| Subarachnoid haemorrhage | UKBB | 1084 | 366 559 | 367 643 | European |
| Heart and valvular disease | |||||
| Coronary artery disease | CARDIoGRAMplusC4D consortium | 60 801 | 123 504 | 184 305 | Mix |
| Coronary artery disease | UKBB | 24 531 | 343 112 | 367 643 | European |
| Heart failure | UKBB | 7382 | 387 652 | 395 034 | European |
| Atrial fibrillation | AFGen | 65 446 | 522 000 | 587 446 | Mix |
| Atrial fibrillation | UKBB | 16 945 | 350 698 | 367 643 | European |
| Abdominal aortic aneurysm | UKBB | 1094 | 366 549 | 367 643 | European |
| Aortic valve stenosis | UKBB | 2244 | 365 399 | 367 643 | European |
| Vessel disease | |||||
| Peripheral artery disease | UKBB | 3415 | 364 228 | 367 643 | European |
| Venous thromboembolism | UKBB | 15 602 | 352 041 | 367 643 | European |
| Cancer | |||||
| Bladder cancer | UKBB | 2588 | 365 055 | 367 643 | European |
| Breast cancer | BCAC | 122 977 | 105 974 | 228 951 | Mix |
| Breast cancer ER- | BCAC | 21 468 | NA | NA | Mix |
| Breast cancer ER+ | BCAC | 69 501 | NA | NA | Mix |
| Breast cancer | UKBB | 13 666 | 353 977 | 198 838 | European |
| Cervical cancer | UKBB | 1928 | 365 715 | 198 838 | European |
| Colorectal cancer | UKBB | 5486 | 362 157 | 367 643 | European |
| Endometrial cancer | UKBB | 1520 | 366 123 | 198 838 | European |
| Head-neck cancer | UKBB | 1615 | 366 028 | 367 643 | European |
| Kidney cancer | UKBB | 1310 | 366 333 | 367 643 | European |
| Leukaemia | UKBB | 1403 | 366 240 | 367 643 | European |
| Lung cancer | ILCCO | 11 348 | 15,861 | 27 209 | European |
| Melanoma | UKBB | 4869 | 362 774 | 367 643 | European |
| Non-Hodgkin's lymphoma | UKBB | 2296 | 365 347 | 367 643 | European |
| Ovarian cancer | UKBB | 1520 | 366 123 | 198 838 | European |
| Ovarian cancer | OCAC | 22 406 | 40 941 | 63 347 | Mix |
| Overall cancer | UKBB | 75 037 | 292 606 | 367 643 | European |
| Pancreatic cancer | UKBB | 1264 | 366 379 | 367 643 | European |
| Prostate cancer | PRACTICAL | 79 194 | 61 112 | 140 306 | European |
| Prostate cancer | UKBB | 7872 | 359 771 | 168 748 | European |
AFGen indicates Atrial Fibrillation Consortium; BCAC, Breast Cancer Association Consortium; CARDIoGRAMplusC4D, Coronary ARtery DIsease Genome wide Replication and Meta-analysis plus The Coronary Artery Disease Genetics; GARNET, Genetics and Allied research in Rheumatic diseases Networking; ILCCO, The International Lung Cancer Consortium; NA, not available; OCAC, The Ovarian Cancer Association Consortium; PRACTICAL, The Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome consortium; UKBB, UK Biobank; UK IBD consortium, UK Inflammatory Bowel Disease Genetics Consortium.
Includes Crohn's disease and ulcerative colitis.