Fig. 1.

Peg-IFNα2a treatment induces the proportion of the pro-inflammatory, bisecting GlcNAc glycans on plasma IgG. (A) A schematic of the clinical study from which samples had been obtained. (B) Violin plots of the IgG glycan structures that were modulated by IFNα. Nineteen glycan structures (displayed on the bottom half of the graph) are grouped into seven groups (displayed in the top half of the graph), depending on the presence or absence of four monosaccharides: bisecting GlcNAc (B group), sialic acid (S1 and S2 groups), galactose (G0, G1, and G2 groups), or fucose (F group). Wilcoxon signed-rank test. (C-G) Bar graphs of selected B group IgG glycan structures modulated by IFNα. Wilcoxon signed-rank test. Lines represent medians. FDR values were calculated using the Benjamini–Hochberg method. N = 18 for study visits 8 and 13, and n = 7 for study visit 25.