Fig. 3.

Interaction network of IFNα-mediated modulation of the IgG glycomes, plasma inflammatory markers, and CD8⁺ T and NK cell phenotypes. Circos plots describe the correlations between Peg-IFNα2a-mediated changes in the IgG glycomes (orange), plasma markers of inflammation and immune activation (fuchsia), and (A) CD8⁺ T cell (green) and (B) K652-stimulated NK cell (light teal) phenotypes. Interactions in which all three domains (IgG glycomes, soluble plasma markers of inflammation, and immune cell phenotype) significantly correlate with each other are indicated by the darker red or blue connections. Correlations were evaluated using Spearman's rank correlation tests. N = 8. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)