Fig. 3.

PARP inhibitor drug sensitivity scores per cell line. a Barplot with cell lines ordered according to a PARP inhibitor sensitivity index (the sum of the standardized drug sensitivity score for four PARP inhibitors with veliparib excluded due to low activity/low correlation). Dashed horizontal line indicates value used for dichotomy in downstream analyses. Samples are coloured according to MSI-status (dark grey: MSI; grey: MSS; white: unknown). Histogram shows distribution of PARP inhibitor drug sensitivity scores among 93 cell lines. b Comparison of potency of the five PARP inhibitors based on drug sensitivity scores in the eight cell lines classified as PARP inhibitor sensitive. P values are from paired-samples t-tests.