Multi-Inflammatory Syndrome in Children related to SARS-CoV-2 in Spain

Cinta Moraleda; Miquel Serna-Pascual; Antoni Soriano-Arandes; Silvia Simó; Cristina Epalza; Mar Santos; Carlos Grasa; Maria Rodríguez; Beatriz Soto; Nerea Gallego; Yolanda Ruiz; María Urretavizcaya-Martínez; Marta Pareja; Francisco José Sanz-Santaeufemia; Victoria Fumadó; Miguel Lanaspa; Iolanda Jordan; Luis Prieto; Sylvia Belda; Belén Toral-Vázquez; Elena Rincón; Nuria Gil-Villanueva; Ana Méndez-Echevarría; Ana Castillo-Serrano; Jacques G Rivière; Pere Soler-Palacín; Pablo Rojo; Alfredo Tagarro

doi:10.1093/cid/ciaa1042

. 2020 Jul 25:ciaa1042. doi: 10.1093/cid/ciaa1042

Multi-Inflammatory Syndrome in Children related to SARS-CoV-2 in Spain

Cinta Moraleda ^1,², Miquel Serna-Pascual ², Antoni Soriano-Arandes ³, Silvia Simó ⁴, Cristina Epalza ¹, Mar Santos ⁵, Carlos Grasa ⁶, Maria Rodríguez ⁷, Beatriz Soto ⁸, Nerea Gallego ⁹, Yolanda Ruiz ¹⁰, María Urretavizcaya-Martínez ¹¹, Marta Pareja ¹², Francisco José Sanz-Santaeufemia ¹³, Victoria Fumadó ⁴, Miguel Lanaspa ⁴, Iolanda Jordan ¹⁴, Luis Prieto ¹, Sylvia Belda ¹⁵, Belén Toral-Vázquez ¹⁶, Elena Rincón ⁵, Nuria Gil-Villanueva ¹⁷, Ana Méndez-Echevarría ⁶, Ana Castillo-Serrano ¹², Jacques G Rivière ³, Pere Soler-Palacín ³, Pablo Rojo ^1,², Alfredo Tagarro ^2,^18,^✉, on behalf of EPICO-AEP Working Group.

¹ Pediatric Infectious Diseases Unit. Department of Pediatrics, Hospital Universitario 12 de Octubre. Madrid, Spain

²Pediatric Research and Clinical Trials Unit (UPIC). Instituto de Investigación Sanitaria Hospital 12 de Octubre (IMAS12), Madrid, Spain. Fundación para la Investigación Biomédica del Hospital 12 de Octubre, Madrid, Spain. RITIP (Traslational Research Network in Pediatric Infectious Diseases)

³ Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d’Hebron Research Institute, Barcelona, Spain

⁴ Infectious and Imported Diseases Unit, Department of Pediatrics, Sant Joan de Déu Universitary Hospital Research Foundation, Barcelona, Spain

⁵ Pediatric Infectious Diseases Unit, Hospital Universitario Gregorio Marañón, Madrid, Spain

⁶Pediatrics and Infectious Disease Unit. Pediatrics Department, Hospital Universitario La Paz. Fundación IdiPaz. Madrid. España. Red de Investigación Traslacional en Infectología Pediátrica (RITIP)

⁷ Pediatrics Department. Hospital Universitario Infanta Cristina. Parla, Madrid, Spain

⁸ Pediatrics Department. Hospital Universitario de Getafe. Getafe, Madrid, Spain

⁹ Pediatrics Department. Hospital Universitario Son Espases. Palma de Mallorca, Illes Baleares, Spain

¹⁰ Pediatrics Department. Hospital Universitario San Pedro. Logroño, La Rioja, Spain

¹¹ Pediatrics Department. Complejo Hospitalario de Navarra. Pamplona, Navarra, Spain

¹² Complejo Hospitalario Universitario de Albacete. Albacete, Castilla-La Mancha, Spain

¹³ Pediatrics Department. Hospital Universitario Niño Jesús, Madrid, Spain

¹⁴ Pediatric Intensive Care Unit, Sant Joan de Deu Universitary Hospital, Barcelona, Spain. CIBERES

¹⁵ Pediatric Intensive Care Unit. Department of Pediatrics, Hospital Universitario 12 de Octubre, School of Medicine, Complutense University of Madrid, Mother-Child Health and Development Network (Red SAMID) of Carlos III Health Institute, Madrid, Spain

¹⁶ Pediatric Cardiology Unit. Department of Pediatrics, Hospital Universitario 12 de Octubre, Madrid, Spain

¹⁷ Department of Paediatric Cardiology, H.G.U Gregorio Marañón, Madrid, Spain

¹⁸ Pediatrics Department. Hospital Universitario Infanta Sofía. Pediatrics Research Group. Universidad Europea de Madrid. Madrid, Spain

^✉

Contact author: Alfredo Tagarro García. Servicio de Pediatría, Hospital Infanta Sofía de San Sebastián de los Reyes, Madrid. Spain. E-mail: alfredotagarro@gmail.com

PMCID: PMC7454331 PMID: 32710613

Abstract

Some clusters of children with a multisystem inflammatory syndrome associated with SARS-CoV-2 infection (MIS-C) have been reported. We describe the epidemiological and clinical features of children with MIS-C in Spain. MIS-C is a potentially severe condition that presents in children with recent SARS-CoV-2 infection.

Keywords: Multisystem inflammatory syndrome, Pediatric inflammatory multisystemic syndrome, COVID-19, SARS-CoV-2, Kawasaki disease

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Multi-Inflammatory Syndrome in Children related to SARS-CoV-2 in Spain

Cinta Moraleda, MD, PhD

Miquel Serna-Pascual

Antoni Soriano-Arandes, MD, PhD

Silvia Simó, MD

Cristina Epalza, PhD, MD

Mar Santos, PhD, MD

Carlos Grasa, MD

Maria Rodríguez, MD

Beatriz Soto, MD, PhD

Nerea Gallego, MD

Yolanda Ruiz, MD

María Urretavizcaya-Martínez, MD

Marta Pareja, MD

Francisco José Sanz-Santaeufemia, PhD, MD

Victoria Fumadó, MD, PhD

Miguel Lanaspa, MD, PhD

Iolanda Jordan, MD, PhD

Luis Prieto, MD, PhD

Sylvia Belda, MD

Belén Toral-Vázquez, MD

Elena Rincón, MD

Nuria Gil-Villanueva, MD

Ana Méndez-Echevarría, MD, PhD

Ana Castillo-Serrano, MD

Jacques G Rivière, MD

Pere Soler-Palacín, MD, PhD

Pablo Rojo, MD, PhD

Alfredo Tagarro, MD, PhD

Abstract

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PERMALINK

Multi-Inflammatory Syndrome in Children related to SARS-CoV-2 in Spain

Cinta Moraleda, MD, PhD

Miquel Serna-Pascual

Antoni Soriano-Arandes, MD, PhD

Silvia Simó, MD

Cristina Epalza, PhD, MD

Mar Santos, PhD, MD

Carlos Grasa, MD

Maria Rodríguez, MD

Beatriz Soto, MD, PhD

Nerea Gallego, MD

Yolanda Ruiz, MD

María Urretavizcaya-Martínez, MD

Marta Pareja, MD

Francisco José Sanz-Santaeufemia, PhD, MD

Victoria Fumadó, MD, PhD

Miguel Lanaspa, MD, PhD

Iolanda Jordan, MD, PhD

Luis Prieto, MD, PhD

Sylvia Belda, MD

Belén Toral-Vázquez, MD

Elena Rincón, MD

Nuria Gil-Villanueva, MD

Ana Méndez-Echevarría, MD, PhD

Ana Castillo-Serrano, MD

Jacques G Rivière, MD

Pere Soler-Palacín, MD, PhD

Pablo Rojo, MD, PhD

Alfredo Tagarro, MD, PhD

Abstract

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