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Oxford University Press - PMC COVID-19 Collection logoLink to Oxford University Press - PMC COVID-19 Collection
. 2020 Aug 8:ciaa1165. doi: 10.1093/cid/ciaa1165

Cerebrospinal fluid features in SARS-CoV-2 RT-PCR positive patients

Mathilde Bellon 1,2,7,#,, Cecilia Schweblin 1,2,7,#, Nathalie Lambeng 3,#, Pascal Cherpillod 1, Jessica Vazquez 3, Patrice H Lalive 5,6,7,#, Manuel Schibler 1,2,#, Christine Deffert 3,4,#
PMCID: PMC7454353  PMID: 32770235

Abstract

This study analyzed the cerebrospinal fluid features of 31 COVID-19 patients with neurological complications. We observed neither SARS-CoV-2 RNA in the cerebrospinal fluid, nor intrathecal IgG synthesis, but did observe signs of blood-brain barrier disruption. These results might serve as a basis for a better understanding of SARS-CoV-2 related neuropathogenesis.

Keywords: SARS-CoV-2, neurological manifestations, COVID-19, intrathecal synthesis, blood-brain barrier


Articles from Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America are provided here courtesy of Oxford University Press

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