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. 2020 Jun 5;9(1):1776577. doi: 10.1080/2162402X.2020.1776577

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — The vascular differences in immunodeficient and immunocompetent hosts of DIPG, GBM1, and GBM551 tumors. (a) Collagen IV staining showed the different blood vessel morphologies in DIPG, GBM1, and GBM551 mice. The scale bar is 50 μm. (b) Quantification analysis of blood vessel diameter showed enhanced vascularization of tumors in immunocompetent mice. N = 180 blood vessels from three animals/group (60 blood vessels for each animal). Median with IQR, ** p< 0.01, Mann–Whitney U test. (c) Quantification analysis of Collagen IV intensity showed more blood supply of GBM1 tumor in immunocompetent mice. N = 9 slices from three animals/group (three brain slices for each animal). Mean ± SD, **p < 0.01, n.s. is no significant difference, independent t-test.