Table 4.
Differential changes (% change) within and between subgroups from baseline (pre weight-loss) to Week 12 (post weight-loss).
| 1. Male (p, pre vs. post) |
2. Female (p, pre vs. post) |
p, 1 vs. 2 | 3. HIBMI (p, pre vs. post) |
4. LOBMI (p, pre vs. post) |
p, 3 vs. 4 | 5. HIAG (p, pre vs. post) |
6. LOAG (p, pre vs. post) |
p, 5 vs. 6 | 7. HIres (p, pre vs. post) |
8. LOres (p, pre vs. post) |
p, 7 vs. 8 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Body weight | 12.9 ± 4.9 (<0.01) | 9.0 ± 4.3 (<0.01) | 0.03 | 10.2 ± 5.4 (<0.01) | 9.6 ± 2.7 (<0.01) | NS | 10.8 ± 4.4 (<0.01) | 8.6 ± 5.1 (<0.01) | NS | 13.2 ± 3.6 (<0.01) | 6.8 ± 3.3 (<0.01) | <0.01 |
| BMI | 12.9 ± 4.9 (<0.01) | 9.03 ± 4.29 (<0.01) | 0.03 | 10.2 ± 5.44 (<0.01) | 9.6 ± 2.7 (<0.01) | NS | 10.8 ± 4.36 (<0.01) | 8.6 ± 5.1 (<0.01) | NS | 13.7 ± 5.0 (<0.01) | 6.8 ± 3.3 (<0.01) | <0.01 |
| Hip | 6.3 ± 3.3 (<0.01) | 5.9 ± 4.2 (<0.01) | NS | 6.5 ± 4.4 (<0.01) | 5.1 ± 2.6 (<0.01) | NS | 5.7 ± 4.1 (<0.01) | 6.7 ± 3.6 (<0.01) | NS | 7.8 ± 4.0 (<0.01) | 4.3 ± 3.1 (<0.01) | <0.01 |
| Waist | 10.6 ± 3.8 (<0.01) | 7.0 ± 5.3 (<0.01) | 0.07 | 8.1 ± 6.0 (<0.01) | 7.4 ± 3.3 (<0.01) | NS | 9.1 ± 4.7 (<0.01) | 5.7 ± 5.5 (<0.01) | 0.06 | 9.8 ± 4.7 (<0.01) | 5.9 ± 5.0 (<0.01) | 0.02 |
| Waist:hip | 4.6 ± 2.9 (<0.01) | 1.0± 5.6 (NS) | 0.07 | 1.6 ± 6.2 (0.09) | 2.5 ± 2.8 (0.01) | NS | 3.6 ± 3.8 (<0.01) | −1.1 ± 6.2 (NS) | <0.01 | 2.2 ± 4.9 (0.04) | 1.6 ± 5.7 (NS) | NS |
| Total FM | 24.1 ± 9.3 (<0.01) | 13.9 ± 7.1 (<0.01) | <0.01 | 15.1 ± 8.6 (<0.01) | 19.1 ± 9.1 (<0.01) | NS | 17.4 ± 8.6 (<0.01) | 14.8 ± 9.3 (<0.01) | NS | 21.4 ± 7.6 (<0.01) | 11.5 ± 7.1 (<0.01) | <0.01 |
| Total FFM | 7.2 ± 4.7 (<0.01) | 5.1 ± 3.8 (<0.01) | NS | 6.2 ± 4.7 (<0.01) | 4.6 ± 2.1 (<0.01) | NS | 6.4± 4.1 (<0.01) | 4.4 ± 3.9 (<0.01) | NS | 7.4 ± 4.0 (<0.01) | 4.0 ± 3.6 (<0.01) | 0.01 |
| Body fat% | 13.3 ± 7.3 (<0.01) | 5.7 ± 4.9 (<0.01) | <0.01 | 6.1 ± 4.9 (<0.01) | 10.8 ± 8.0 (<0.01) | 0.04 | 7.9 ± 6.5 (<0.01) | 7.2 ± 6.4 (<0.01) | NS | 10.0 ± 6.3 (<0.01) | 5.2 ± 5.7 (<0.01) | 0.02 |
| Android FM | 32.5 ± 16.8 (<0.01) | 18.5 ± 8.3 (<0.01) | <0.01 | 19.4 ± 11.3 (<0.01) | 27.3 ± 13.2 (<0.01) | 0.07 | 22.4 ± 12.7 (<0.01) | 21.3 ± 12.2 (<0.01) | NS | 27.4 ± 13.5 (<0.01) | 16.6 ± 8.4 (<0.01) | <0.01 |
| AndroidFFM | 12.6 ± 10.0 (<0.01) | 7.6 ± 5.4 (<0.01) | 0.07 | 9.3 ± 7.5 (<0.01) | 8.0 ± 6.0 (<0.01) | NS | 9.4 ± 7.0 (<0.01) | 7.9 ± 7.2 (<0.01) | NS | 11.5 ± 7.8 (<0.01) | 6.2 ± 5.0 (<0.01) | 0.02 |
| AndroidFat% | 12.2 ± 12.4 (0.02) | 5.5 ± 4.8 (<0.01) | 0.02 | 5.3 ± 7.1 (<0.01) | 10.8 ± 8.2 (< 0.01) | 0.05 | 6.7 ± 8.3 (<0.01) | 8.0 ± 7.0 (<0.01) | NS | 8.4 ± 10.1 (<0.01) | 5.9 ± 4.4 (<0.01) | NS |
| Gynoid FM | 23.2 ± 10.7 (<0.01) | 14.2 ± 7.1 (<0.01) | <0.01 | 15.9 ± 9.1 (<0.01) | 17.5 ± 8.9 (<0.01) | NS | 17.2 ± 9.1 (<0.01) | 15.1 ± 8.7 (<0.01) | NS | 21.8 ± 8.1 (<0.01) | 11.1 ± 6.1 (<0.01) | <0.01 |
| Gynoid FFM | 10.0 ± 7.4 (<0.01) | 6.8 ± 5.5 (<0.01) | NS | 8.0 ± 6.6 (<0.01) | 6.9 ± 4.9 (<0.01) | NS | 8.5 ± 6.1 (<0.01) | 6.0 ± 5.8 (<0.01) | NS | 9.4 ± 6.0 (<0.01) | 5.9 ± 5.7 (<0.01) | 0.08 |
| Gynoid Fat% | −1.08 ± 5.16 (NS) | 0.3±5.2 (NS) | NS | 0.9 ± 4.5 (NS) | −2.1 ± 5.9 (NS) | NS | −0.3 ± 5.7 (NS) | 0.2 ± 4.1 (NS) | NS | 0.6 ± 4.3 (NS) | −0.7 ± 5.9 (NS) | NS |
| AG | 13.1 ± 11.9 (<0.01) | 5.0 ± 7.5 (<0.01) | 0.02 | 4.3 ± 7.9 (0.02) | 12.3 ± 9.9 (<0.01) | 0.01 | 6.6 ± 10.2 (<0.01) | 7.7 ± 7.7 (<0.01) | NS | 7.7 ± 11.3 (0.01) | 6.3±7.0 (<0.01) | NS |
| A1C | 6.1 ± 8.6 (0.08) | 4.7 ± 8.4 (<0.01) | NS | 4.6 ± 8.1 (0.01) | 5.9 ± 9.2 (0.04) | NS | 5.4 ± 9.3(0.01) | 4.4 ± 6.7 (0.04) | NS | 6.5 ± 9.0 (<0.01) | 3.2 ± 7.5 (0.07) | NS |
| Systolic BP | 8.9 ± 9.1 (0.02) | 8.2 ± 11.2 (<0.01) | NS | 7.9 ± 9.8 (<0.01) | 9.2 ± 12.3 (0.03) | NS | 10.0±10.6 (<0.01) | 5.7 ± 10.4 (0.07) | NS | 9.1 ± 10.6 (<0.01) | 7.7 ± 10.8 (<0.01) | NS |
| Diastolic BP | 7.9 ± 10.5 (0.05) | 10.5 ± 10.6 (<0.01) | NS | 10.6 ± 9.2 (< 0.01) | 8.3 ± 12.9 (0.05) | NS | 10.2±10.0 (<0.01) | 9.3 ± 11.7 (0.02) | NS | 9.6 ± 10.7 (<0.01) | 10.0 ± 10.7 (<0.01) | NS |
| Heart rate | 11.0 ± 14.1 (0.06) | −0.3 ± 14.6 (NS) | 0.05 | 3.9 ± 14.9 (NS) | 0.1 ± 16.1 (NS) | NS | 1.3 ± 13.3 (NS) | 4.8 ± 18.3 (NS) | NS | 6.5 ± 15.1 (0.08) | 1.1 ± 14.6 (NS) | NS |
Percent change data from baseline are shown as mean ± SD; positive values indicate decrease and negative values indicate increase from baseline to Week 12; p ≤ 0.05 (significant) and p = 0.06–0.08 (trend) shown, the rest noted as NS (not-significant and no trend). BMI, body mass index; FM, fat mass; FFM, fat free mass; AG, android to gynoid fat ratio; BP, blood pressure; A1C, percentage glycated hemoglobin; HI, high; LO, low; res, response.