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. 2020 Aug 6;9(8):1841. doi: 10.3390/cells9081841

Figure 3.

Figure 3

circRNAs acting as decoy, scaffold, and recruiter molecules. Depending on the conditions, some circRNAs may exert several activities. circ-PABPN1 can decoy the human antigen R (HuR) protein in HeLa cells, thereby preventing HuR from attaching to PABPN1 mRNA, inhibiting PABN1 mRNA translation and resulting in decreased cell proliferation [134]. The circ-FOXO3 scaffold p53 and MDM2 cause ubiquitin-dependent p53 degradation and, at the same time, decrease FOXO3 ubiquitination. Reduced p53 and increased FOXO3 levels result in enhanced cell apoptosis in cancer cell lines [132]. circ-Amolt1 recruits STAT3 and changes its location from the cytoplasm back to the nucleus in skin fibroblasts. The circ-Amotl1-STAT3 complex promotes Dnmt3a transcription, which in turn inhibits the miR17-5p production. Decreased miR17-5p results in STAT3, Dnmt3a, and fibronectin overexpression, thus activating cell proliferation, which is critical in the wound healing process [130].