Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 5;12(8):734. doi: 10.3390/pharmaceutics12080734

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

3D surfaces of the thicknesses extracted from the acquired and processed data. (a) The 3D surface on the left is related to the thickness of the cartilage cell structure computed from the CARS signal, in the center, the 3D surface is related to thickness of the collagen and thus the ECM from the SHG signal, while on the right the 3D surface is related to the EV penetration depths in the cartilage after 5 h from the TPEF signal; (b) the 3D surfaces show the dynamic of the EV penetration in the cartilage during the time-lapse; in the top right corner of each image the related timeframe is depicted; (c) the 3D surfaces show the dynamic of the EV penetration in the chondrocytes micromass during the time-lapse, in the top right corner of each image the related timeframe is depicted.

3D surfaces of the thicknesses extracted from the acquired and processed data. (a) The 3D surface on the left is related to the thickness of the cartilage cell structure computed from the CARS signal, in the center, the 3D surface is related to thickness of the collagen and thus the ECM from the SHG signal, while on the right the 3D surface is related to the EV penetration depths in the cartilage after 5 h from the TPEF signal; (b) the 3D surfaces show the dynamic of the EV penetration in the cartilage during the time-lapse; in the top right corner of each image the related timeframe is depicted; (c) the 3D surfaces show the dynamic of the EV penetration in the chondrocytes micromass during the time-lapse, in the top right corner of each image the related timeframe is depicted.