Table 1.
Top 10 differentially upregulated genes identified by genome-wide human expression microarrays. * Genes were considered significantly differentially expressed when (a) a t-test p-value was less than 0.05 and (b) a cutoff in transcript abundance reached at least 1.5-fold change. The 10 most upregulated genes for each strain are displayed in the table.
| EME343 | EME394 | EME126 | EME141 | EMS321 | EMS383 | EMS3101 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Fold Change | Gene | Fold Change | Gene | Fold Change | Gene | Fold Change | Gene | Fold Change | Gene | Fold Change | Gene | Fold Change |
| IL8 | 14.502 | IL8 | 12.219 | IL8 | 8.043 | CCL2 | 4.718 | ATF3 | 5.989 | CCL2 | 6.741 | SNORD3B-1 | 4.091 |
| CCL2 | 9.667 | CCL20 | 11.190 | CCL2 | 6.391 | GADD45A | 3.706 | IL8 | 5.036 | C1QTNF9 | 6.711 | HIST2H2AA4 | 3.981 |
| ATF3 | 7.888 | IL1A | 9.573 | TNFAIP3 | 4.777 | PTX3 | 3.620 | CCL2 | 3.968 | SULT1B1 | 5.156 | CCL2 | 3.108 |
| TNFAIP3 | 6.536 | CXCL2 | 7.994 | CLDN1 | 3.609 | DDIT3 | 3.497 | EGR1 | 3.734 | CLDN1 | 4.469 | SLC5A7 | 3.086 |
| PTX3 | 6.242 | CCL2 | 7.351 | IER3 | 3.527 | CLDN1 | 3.257 | STC2 | 3.732 | CHAC1 | 4.310 | HIST1H2BI | 3.074 |
| CDKN1A | 6.132 | PTX3 | 5.996 | NDRG1 | 3.296 | STC2 | 3.160 | PTX3 | 3.420 | ATF3 | 4.124 | HIST1H2AC | 2.910 |
| IL1A | 6.088 | EGR1 | 4.945 | CXCL1 | 3.220 | CXCL2 | 3.052 | DDIT3 | 3.307 | ASNS | 4.020 | HIST1H2BC | 2.848 |
| SLC7A11 | 5.094 | STC2 | 4.444 | PTX3 | 2.892 | MAFF | 2.901 | CHAC1 | 3.166 | TRIB3 | 3.930 | HIST2H4B | 2.759 |
| EGR1 | 4.936 | ATF3 | 4.391 | CSN1S1 | 2.471 | PPP1R15A | 2.601 | CLDN1 | 3.116 | STC2 | 3.792 | HIST1H4L | 2.676 |
| CXCL2 | 4.823 | CHAC1 | 4.344 | CEBPB | 2.432 | EGR1 | 2.573 | VEGFA | 2.963 | SLC7A11 | 3.502 | HIST4H4 | 2.593 |