Figure 2.

Associations between plasma levels of 112 metabolites and incident cardiovascular disease (CVD) in participants with diabetes from the Malmö Diet and Cancer-Cardiovascular Cohort (MDC-CC) (n = 357) and the Malmö Preventive project (MPP) (n = 315). The 10log hazard ratios (logHR) were calculated separately in MDC-CC and MPP from cox regression models (adjusted for age and sex) and subsequently meta-analyzed using inverse variance-weighted meta-analysis, using fixed estimates. LogHR of all-cause mortality is expressed per standard deviation increment of each metabolite. Associations were considered significant at a false-discovery rate <0.05. −logp= −10log of the p-value.