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. 2020 Aug 4;12(8):731. doi: 10.3390/pharmaceutics12080731

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The influences of concentration (a), intestinal sections (b), and inhibitors (c) on the Papp of TIL-SLNs or tilmicosin solution. The absorption site of tilmicosin was shifted from ileum to duodenum via TIL-SLNs. The absorption efficiency of TIL-SLNs was hindered by P-gp. Note: (a), the Papp of various concentration of TIL-SLNs; (b), the Papp of TIL-SLNs in various intestine sections; ND: TIL-SLNs duodenum; SD: solution duodenum; NJ: TIL-SLNs jejunum; SJ: solution jejunum; NI: TIL-SLNs ileum; SI: solution ileum. ^a Statistically significant from TIL-SLNs duodenum; ^b Statistically significant from solution duodenum; ^c Statistically significant from TIL-SLNs jejunum; ^d Statistically significant from solution jejunum; (c), T-80: polysorbate-80, ^a Statistically significant from TIL-SLNs (0.125 mg/mL); ^b Statistically significant from verapamil; ^c Statistically significant from indomethacin; ^d Statistically significant from EDTA-2Na; ^e Statistically significant from 0.5% T-80. The statistical difference was analyzed by one-way analysis of variance at p < 0.05.

The influences of concentration (a), intestinal sections (b), and inhibitors (c) on the Papp of TIL-SLNs or tilmicosin solution. The absorption site of tilmicosin was shifted from ileum to duodenum via TIL-SLNs. The absorption efficiency of TIL-SLNs was hindered by P-gp. Note: (a), the Papp of various concentration of TIL-SLNs; (b), the Papp of TIL-SLNs in various intestine sections; ND: TIL-SLNs duodenum; SD: solution duodenum; NJ: TIL-SLNs jejunum; SJ: solution jejunum; NI: TIL-SLNs ileum; SI: solution ileum. ^a Statistically significant from TIL-SLNs duodenum; ^b Statistically significant from solution duodenum; ^c Statistically significant from TIL-SLNs jejunum; ^d Statistically significant from solution jejunum; (c), T-80: polysorbate-80, ^a Statistically significant from TIL-SLNs (0.125 mg/mL); ^b Statistically significant from verapamil; ^c Statistically significant from indomethacin; ^d Statistically significant from EDTA-2Na; ^e Statistically significant from 0.5% T-80. The statistical difference was analyzed by one-way analysis of variance at p < 0.05.