Table 2.

Identified metabolites list obtained from UPLC-Q-TOF MS and identified sterol metabolites from multiple reaction monitoring (MRM) data of rats fed ginseng.

	Metabolite	p-Value a	VIP b	Fold Change (vs. Control)
				GL	GH
Kidney	uracil	1.83 × 102	0.94	−1.14	−1.19
	glutathione, oxidized	5.64 × 104	1.40	−2.78	−2.87
	succinyladenosine	1.23 × 102	0.95	−1.50	−1.00
	riboflavin	2.00 × 103	1.21	−1.01	1.35
	leucyl histidine	2.51 × 105	1.45	−1.02	−1.50
	stearoylcarnitine	2.70 × 102	0.96	1.47	1.60
Liver	carnitine	3.30 × 102	1.10	1.06	1.46
	LPE(C20:4)	2.40 × 103	2.54	1.16	1.57
	LPC(C18:1)	2.24 × 102	1.58	1.21	−1.33
Plasma	LPE(C18:3)	7.05 × 104	0.69	−2.18	−2.66
	LPC(C16:1)	1.04 × 104	0.55	−2.19	−3.97
	LPC(C20:4)	7.56 × 105	1.00	−2.20	−4.50
	LPC(C18:2)	1.46 × 104	2.48	−2.16	−4.62
	LPC(C18:3)	1.23 × 103	0.17	−2.32	−3.39
	LPC(C16:0)	4.12 × 105	3.28	−2.15	−3.93
	LPC(C18:1)	2.12 × 104	1.88	−2.76	−6.58
	LPC(C17:0)	3.55 × 105	0.49	−3.20	−7.34
	LPC(C18:0)	5.20 × 105	2.41	−3.03	−5.90
	Estradiol-3-glucuronate	1.08 × 102	0.96	1.10	−1.03
	estrone-3-hemisuccinate	9.92 × 103	1.00	1.47	−1.30
	11α-hydroxyestradiol	2.62 × 1023	0.79	1.13	1.10
	21α-hydroxyprogesterone	3.87 × 103	1.02	1.53	−1.08
Urine	27-hydroxycholesterol	1.78 × 102	0.94	−1.25	1.19
	metandienone	3.76 × 102	0.78	1.26	1.00
	2-hydroxyestrone-1+4-N-acetylcysteine	3.16 × 102	0.90	1.98	2.13
	6-dehydroestradiol diacetate	2.71 × 102	0.95	1.13	1.33
	estriol-16,17-diacetate	2.60 × 102	0.82	2.14	−1.01
	2,3-dimethoxyestradiol	3.57 × 102	0.85	1.48	−1.62
	5-androstenediol	4.17 × 102	0.86	−1.42	−1.43
	11β-hydroxyestradiol derivatives	7.45 × 102	1.86	6.75	6.67

^a Variable importance in the projection (VIP) values were determined by PLS-DA. ^b p-Value were analyzed by ANOVA with Duncan’s test.