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(a) The area under the receiver operating characteristic curve for vitamin C concentration associated with an increased incidence of moderate-to-severe symptoms of tingling, prickling or pins and needles sensation (i.e., NRS ≥ 4); (b) The area under the receiver operating characteristic curve for vitamin C concentration to predict severe tingling, prickling or pins and needles sensation (i.e., NRS ≥ 7).
