Table 2.

SNPs related to coffee consumption (p-value < 1 × 10⁻⁵).

Chr	SNP	Position	Gene	Alleles 1	MAF 2	MAF 3	Beta 4	p-Value 5
12	rs2074356	112,645,401	HECTD4	A/G	0.149	0.129	0.3185	6.62 × 10−8
12	rs11066015	112,168,009	ACAD10	A/G	0.172	0.176	0.2469	7.79 × 10−6
12	rs12229654	111,414,461	MYL2	G/T	0.143	0.159	0.2867	1.49 × 10−6
12	rs11065828	111,629,389	CUX2	A/C	0.172	0.214	0.2654	1.26 × 10−6
12	rs79105258	111,718,231	CUX2	A/C	0.156	0.216	0.2912	3.89 × 10−7

Abbreviations: Chr, chromosome; SNP, single nucleotide polymorphism; MAF, minor allele frequency. ¹ Alleles are presented as minor allele/major allele; ² minor allele frequency in this study population; ³ minor allele frequency in the 1000Genomes, East Asian; ⁴ the beta (β) coefficient was obtained from the GWAS; ⁵ the p-value was calculated using a Wald test from logistic regression model adjusted for age (years; continuous), sex, and alcohol consumption (g/day; continuous).