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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Gastroenterology. 2019 Nov 20;158(4):1044–1057.e17. doi: 10.1053/j.gastro.2019.11.025

Figure 2.

Figure 2.

High-content pairwise miRNA inhibition in vivo. (A) Fah/TuD plasmid libraries were assembled by pooled ligations and administered to male Fah−/− mice. Livers were analyzed four weeks after injection. (B) Immunohistochemical analysis of Fah−/− mouse liver tissue showed numerous FAH-positive repopulation nodules. Scale bar, 500 μm. (C) MBS tallies in enriched and depleted TuDs were negatively correlated in the TuDstd and TuDtail experiments. (D) Depleted (left panel) and enriched (right panel) MBS tallies were significantly correlated between experiments. ◻, Spearman’s rank correlation coefficient.