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Journal of Advanced Research logoLink to Journal of Advanced Research
. 2020 Feb 8;25:11–17. doi: 10.1016/j.jare.2020.01.015

Non-commensurate fractional linear systems: New results

Manuel D Ortigueira a,, Gabriel Bengochea b
PMCID: PMC7474198  PMID: 32922969

Graphical abstract

graphic file with name ga1.jpg

Keywords: Non-commensurate order, Fractional Calculus, Partial fraction decomposition, Laplace transform

Highlights

  • It presents a partial fraction decomposition of non commensurate systems.

  • Suitable inversion of each fraction is done in two ways: series and integer/fractional decomposition.

Abstract

A study of non-commensurate fractional linear system is done in a parallel way to the commensurate case. A partial fraction decomposition is accomplished using a recursive procedure. Each partial fraction is inverted in two different ways. The decomposition integer/fractional is done also. Some examples are presented.

Introduction

The last 30 years of Fractional Calculus [5], [14], [15] brought a remarkable progress and became popular in many scientific and technical areas [4], [6], [7], [8], [9], [16] due to its ability to better describe many natural phenomena. The fact that fractional models represent systems which require lower number of parameter than those of integer order is a point in favor of fractional systems (see [2]). This is due to their capacity of supplying us with more reliable time and frequency representations.

We cannot say that there many works on non-commensurate systems. The first meaningful study was presented in [13], based on a manipulation of the transfer function and the use of the properties of Laplace transform. Another one described in [12] was based on a series expansion of the transfer function. Much of the research in fractional systems is developed for commensurate orders in a way that is a direct generalization of traditional formalism. However, most of the methods used to solve commensurate fractional linear systems cannot be easily extended to non-commensurate case. In such situation, we find the partial fraction decomposition very useful in inverting Laplace and Z transforms currently used in the study of linear systems, when performing the computation of the impulse response from the transfer function (TF). The implementation of such inversion using the decomposition of the TF in partial fractions, not only simplifies the procedure, but gives more insight into the characteristics of the system, namely, stability and existing vibration modes. The procedures in [1], [12], [13] are not suitable to display such characteristics, mainly to perform the modal decomposition.

In this paper, we look for obtaining for non-commensurate order systems such kind of decomposition, provided we know the pseudo-pole/zero factorization. We start from the simplest case where we have only two orders and two pseudo-poles and decompose it into a sum of two fractions. From it, we turn to the case of three pseudo-poles. Finally, we deduce the general case and show how add pseudo-zeros. For each term we obtain the inverse LT by using the operational method presented in [1].

The paper is organized as follows. Firstly, we present our results related to simple fraction decomposition with non-commensurate order. Then, we resolve several examples of lineal fractional systems with non-commensurate order. We continue with the decomposition of transfer function in two parts, a part of integer order and the other one of fractional order. Finally, the conclusions are presented.

Partial fraction decomposition

Non-commensurate transfer function

Consider a linear system with TF given by

H(s)=(sβ1-ζ1)(sβ2-ζ2)(sβm-ζm)(sα1-γ1)(sα2-γ2)(sαn-γn), (1)

where the γi,i=1,2,,n,ζj,j=1,,m, are non-null pseudo-poles and pseudo-zeroes that are, not necessarily different, complex numbers. The derivative orders, βm,αn are real numbers in the interval (0,1), and for stability reasons, mβmnαn.

In applications, we have a problem not easily solvable: the obtention of the factorization. To understand the difficulties we consider the relation between the factorization and the pseudo-polynomial. Consider a pseudo-polynomials with format

Pn(s)=(sα1-γ1)(sα2-γ2)(sαn-γn), (2)

where the γi’s are different complex numbers. Let α=(α1,α2,,αn)R+n. If we define

λ=k=1nαk,λj1=k=1kj1nαk,j1[1,n],λj1,j2=k=1kj1,j2nαk,j1j2,j1,j2[1,n],=λj1,j2,,jn-1=αjn,λj1,j2,,jn=0,

then (2) can be written as

Pn(s)=sλ-j1=0nγj1sλj1+j1,j2=0j1j2nγj2γj1sλj1,j2-j1,j2,j3=0j1j2j3nγj3γj2γj1sλj1,j2,j3++(-1)n+1γjnγj2γj1, (3)

which shows that there are many non-factorizable pseudo-polynomials. For example, sα+asβ+b, with non-commensurate orders does not have a factorization as referred. Relation (3) can serve as guide for obtaining the factorization of polynomials with a few factors.

Two pseudo-poles case

The simple fraction decomposition is a widely used tool in several areas of science. In the case of one variable, a well known simple result is that

1(z-a)(z-b)=1-b+a(z-a)-1-b+a(z-b),ab. (4)

Our goal is the decomposition of a fraction of the type:

1(sα1-γ1)(sα2-γ2),

but it is a simple task to show that it is not possible to obtain a result equal to (4). However, we can obtain a similar decomposition using a trick: if we define in (4) the parameters z=1,a=sα1γ1 and b=sα2γ2, with γ1,γ2 be different non-zero complex numbers, then we obtain the result stated in next Theorem.

Theorem 1

Let γ1,γ2 be different non-null complex numbers and α1,α2 be positive real numbers. Then

1(sα1-γ1)(sα2-γ2)=γ1(sα1-γ1)(γ1sα2-γ2sα1)-γ2(sα2-γ2)(γ1sα2-γ2sα1).

Remark 1

If γ1=γ2=0, the theorem does not apply, because we have no pseudo-pole, but only a branchcut point. For γ10 and γ2=0, we observe that 1(sα1-γ1)sα2=s-α2(sα1-γ1). Therefore, we invert 1(sα1-γ1) and afterwards perform the anti-derivation corresponding to s-α2.

Remark 2

It is important to note that the term (γ1sα2-γ2sα1) has no zeroes in the first Riemann sheet, in the non-commensurate case we are dealing. Therefore, each term in the right hand side in (1) only has a pseudo-pole. If the orders commensurate, we can continue the decomposition as we do in the classic procedure.

General decomposition

In the next theorem, we tackle the case with three simple pseudo-poles.

Theorem 2

Let γ1,γ2,γ3 be different non-null complex numbers, and α1,α2,α2 be positive real numbers. Then

1(sα1-γ1)(sα2-γ2)(sα3-γ3)=γ12(γ2sα1-γ1sα2)(γ3sα1-γ1sα3)(sα1-γ1)+γ22(γ1sα2-γ2sα1)(γ3sα2-γ2sα3)(sα2-γ2)+γ32(γ2sα3-γ3sα2)(γ1sα3-γ3sα1)(sα3-γ3).

Proof

From Theorem 1, we obtain that

1(sα1-γ1)(sα2-γ2)(sα3-γ3)=-γ1(sα1-γ1)(sα3-γ3)(γ2sα1-γ1sα2)-γ2(sα2-γ2)(sα3-γ3)(γ1sα2-γ2sα1).

Applying again the Theorem 1, it follows that

1(sα1-γ1)(sα2-γ2)(sα3-γ3)=γ12(γ2sα1-γ1sα2)(γ3sα1-γ1sα3)(sα1-γ1)+γ22(γ1sα2-γ2sα1)(γ3sα2-γ2sα3)(sα2-γ2)+γ1γ3(γ2sα1-γ1sα2)(γ1sα3-γ3sα1)(sα3-γ3)+γ2γ3(γ1sα2-γ2sα1)(γ2sα3-γ3sα2)(sα3-γ3).

Finally, simplifying we get the result. □

From Theorem 1, Theorem 2, we deduce the general result.

Theorem 3

Let γ1,γ2,,γn be different non-null complex numbers and α1,α2,,αn positive real numbers. Then

1(sα1-γ1)(sα2-γ2)(sαn-γn)=(-1)n+1i=1nγin-1(sαi-γi)nj=1ji(γjsαi-γisαj).

For the case when we have multiple pseudo-poles we only need to apply several times the Theorems. To illustrate the procedure, we present the next example.

Example 1

Suppose that we want to apply the simple fraction decomposition to transfer function

H(s)=1(sα1-γ1)(sα2-γ2)2.

By the Theorem 1, we have that

1(sα1-γ1)(sα2-γ2)=-γ1(sα1-γ1)(γ2sα1-γ1sα2)-γ2(sα2-γ2)(γ1sα2-γ2sα1).

Then

1(sα1-γ1)(sα2-γ2)2=1(sα2-γ2)-γ1(sα1-γ1)(γ2sα1-γ1sα2)-γ2(sα2-γ2)(γ1sα2-γ2sα1)=-γ1(sα1-γ1)(sα2-γ2)(γ2sα1-γ1sα2)-γ2(sα2-γ2)2(γ1sα2-γ2sα1).

Again by applying Theorem 1, we get that

1(sα1-γ1)(sα2-γ2)2=γ12(sα1-γ1)(γ2sα1-γ1sα2)2+γ1γ2(sα2-γ2)(γ1sα2-γ2sα1)(γ2sα1-γ1sα2)-γ2(sα2-γ2)2(γ2sα2-γ2sα1).

Remark 3

There is an eventually simpler approach to this example that consists in taking the decomposition of Theorem 1 and compute the order 1 derivative relatively to γ2 in both sides of the relation.

Simple pseudo-poles/zeroes cases

Now, we add pseudo-zeros to transfer function (1). We suppose that the number of pseudo-poles is bigger than the number of pseudo-zeroes. We procedure as in Theorem 1, but we add a pseudo-zero θ1 of order α3. A simple computation yields

sα3-θ1(sα1-γ1)(sα2-γ2)=-γ1sα3(γ2sα1-γ1sα2)(sα1-γ1)-γ2sα3(γ1sα2-γ2sα1)(sα2-γ2)-θ1sα1(γ1sα2-γ2sα1)(sα1-γ1)-θ1sα2(γ2sα1-γ1sα2)(sα2-γ2). (5)

For the case of three pseudo-poles and one pseudo-zero we obtain that

sα4-θ1(sα1-γ1)(sα2-γ2)(sα3-γ3)=γ12sα4(γ2sα1-γ1sα2)(γ3sα1-γ1sα3)(sα1-γ1)+γ22sα4(γ1sα2-γ2sα1)(γ3sα2-γ2sα3)(sα2-γ2)+γ32sα4(γ2sα3-γ3sα2)(γ1sα3-γ3sα1)(sα3-γ3)-γ1θ1sα1(γ2sα1-γ1sα2)(γ3sα1-γ1sα3)(sα1-γ1)-γ2θ1sα2(γ1sα2-γ2sα1)(γ3sα2-γ2sα3)(sα2-γ2)-γ3θ1sα3(γ2sα3-γ3sα2)(γ1sα3-γ3sα1)(sα3-γ3).

Now, we can deduce the next Theorem.

Theorem 4

Let γ1,γ2,,γn,θ1, be different non-null complex numbers and α1,α2,,αn,αn+1, be real numbers. Then

sαn+1-θ1(sα1-γ1)(sα2-γ2)(sαn-γn)=(-1)n+1i=1nγin-1sαn+1(sαi-γi)nj=1ji(γjsαi-γisαj)-i=1nγin-2θ1sαi(sαi-γi)nj=1ji(γjsαi-γisαj).

For adding another pseudo-zero θ2, with order αn+2, we apply the previous Theorem and get

(sαn+1-θ1)(sαn+2-θ2)(sα1-γ1)(sα2-γ2)(sαn-γn)=(-1)n+1i=1nγin-1sαn+1+αn+2(sαi-γi)nj=1ji(γjsαi-γisαj)-i=1nγin-2θ1sαi+αn+2(sαi-γi)nj=1ji(γjsαi-γisαj)-(-1)n+1i=1nθ2γin-1sαn+1(sαi-γi)nj=1ji(γjsαi-γisαj)+i=1nγin-2θ1θ2sαi(sαi-γi)nj=1ji(γjsαi-γisαj). (6)

The same procedure can be applied to case of more pseudo-zeros. In the next section we present some examples of our decomposition with zeros.

Commensurate case

In this subsection, we present some particular cases with which we verify some known results.

  • Consider α1=α2 in Theorem 1. Then
    1(sα1-γ1)(sα2-γ2)=-γ1/(γ2-γ1)(sα1-γ1)sα1-γ2/(γ1-γ2)(sα1-γ2)sα1.
    The previous relation can be rewritten as
    1(sα1-γ1)(sα2-γ2)=-γ1γ2-γ11γ1(sα1-γ1)-1γ1sα1-γ2γ1-γ21γ2(sα1-γ2)-1γ2sα1=-1γ2-γ1(sα1-γ1)-1γ1-γ2(sα1-γ2)
  • Now, let 0<α1<1,0<α2<1, and set α1=mα,α2=nα,0<α<1, where m,nN. We want to see if γ1sα2-γ2sα1 has zeroes. Let s=ρeiθ. We can show easily that with
    ρ(m-n)α=γ2γ1,
    and
    θ=arg(γ2)-arg(γ1)(m-n)α,
    we have a zero, if |θ|<π. For example, with γ2 and γ1 real numbers with the same sign, there is a zero and consequently the term γ1sα2-γ2sα1 will contribute with another pseudo-pole to (1), but having different signs there will be no pseudo-pole.
  • Consider α1=α2=α3 in Theorem 2. Then
    1(sα1-γ1)(sα2-γ2)(sα3-γ3)=γ12(γ3-γ1)(γ2-γ1)1s2α1(sα1-γ1)+γ22(γ1-γ2)(γ3-γ2)1s2α1(sα1-γ2)+γ32(γ1-γ3)(γ2-γ3)1s2α1(sα1-γ3).
    The previous relation can be rewritten as
    1(sα1-γ1)(sα2-γ2)(sα3-γ3)=1(γ3-γ1)(γ2-γ1)1sα1-γ1-1sα1-γ1s2α1+1(γ1-γ2)(γ3-γ2)1sα1-γ2-1sα1-γ2s2α1+1(γ1-γ3)(γ2-γ3)1sα1-γ3-1sα1-γ3s2α1.
    Simplifying
    1(sα1-γ1)(sα1-γ2)(sα1-γ3)=1(γ3-γ1)(γ2-γ1)1sα1-γ1+1(γ1-γ2)(γ3-γ2)1sα1-γ2+1(γ1-γ3)(γ2-γ3)1sα1-γ3.
  • Consider α2=2α1 in Theorem 1. Then
    1(sα1-γ1)(sα2-γ2)=1(sα1-γ1)(sα1-γ2)(sα1+γ2).
    Using the case when α1=α2=α3, we get that
    1(sα1-γ1)(s2α1-γ2)=1(-γ12+γ2)1sα1-γ1+1-2γ2(γ1-γ2)1sα1-γ2+12γ2(γ1+γ2)1sα1+γ2.

Computing the impulse response of some fractional linear systems

In this section, in order to illustrate how to use our decomposition, we solve several fractional linear systems using the simple fraction decomposition introduced in the previous section. We show how compute the inverse Laplace transform of our basic elements. To do it, we use the results presented in Appendix A to invert each term of (1) to obtain

L-1-γ1sα1-γ1γ2sα1-γ1sα2=k=0l=0γ12l-kγ2k-lt(2l-k+1)α1+(k-l+1)α2-1Γ(2l-k+1)α1+(k-l+1)α2ε(t),

where ε(t) is the Heaviside unit step function.

Example 2

Consider the system associated to transfer function

H(s)=sα3(sα1-1)(sα2-2). (7)

Suppose that the input x(t)=δ(t). From Theorem 3 we have that

H(s)=-sα3(sα1-1)(2sα1-sα2)-2sα3(sα2-2)(sα2-2sα1).

Using the method presented in Appendix A, the solution associated to basic element

H1(s)=-sα3(sα1-1)(2sα1-sα2)=sα3sα1(sα1-1)(sα2-α1-2),

is given by

y1(t)=k=0l=02k-lt(2l-k+1)α1+(k-l+1)α2-α3-1Γ(2l-k+1)α1+(k-l+1)α2-α3ε(t),

and for

H2(s)=-2sα3(sα2-2)(sα2-2sα1)=sα3sα2(sα2-2)sα1-α2-12,

is

y2(t)=k=0l=022l-kt(2l-k+1)α2+(k-l+1)α1-α3-1Γ(2l-k+1)α2+(k-l+1)α1-α3ε(t).

It follows that

L-1-sα3(sα1-1)(2sα1-sα2)=y1(t),

and

L-1-2sα3(sα2-2)(sα2-2sα1)=y2(t).

Therefore the solution y(t) of system (7) is

y(t)=y1(t)+y2(t). (8)

Now, if we have that x(t)=ε(t) in (7), then we only need calculate the integral (omitting the sum of constant) to (8). Therefore the solution of (7) with x(t)=ε(t) is given by

y(t)=k=0l=02k-lt(2l-k+1)α1+(k-l+1)α2-α3Γ(2l-k+1)α1+(k-l+1)α2-α3+1ε(t)+k=0l=022l-kt(2l-k+1)α2+(k-l+1)α1-α3Γ(2l-k+1)α2+(k-l+1)α1-α3+1ε(t).

Example 3

Consider the system associated to transfer function

H(s)=1(sα1-γ1)(sα2-γ2). (9)

Suppose that the input x(t)=δ(t). From Theorem 3 we have that

H(s)=-γ1(sα1-γ1)(γ2sα1-γ1sα2)-γ2(sα2-γ2)(γ1sα2-γ2sα1).

Using the method presented in Appendix A, the solution associated to basic element

H1(s)=-γ1(sα1-γ1)(γ2sα1-γ1sα2)=1sα1(sα1-γ1)sα2-α1-γ2γ1,

is given by

y1(t)=k=0l=0γ12l-kγ2k-lt(2l-k+1)α1+(k-l+1)α2-1Γ(2l-k+1)α1+(k-l+1)α2ε(t),

and for

H2(s)=-γ2(sα2-γ2)(γ1sα2-γ2sα1)=1sα2(sα2-γ2)sα1-α2-γ1γ2,

is

y2(t)=k=0l=0γ22l-kγ1k-lt(2l-k+1)α2+(k-l+1)α1-1Γ(2l-k+1)α2+(k-l+1)α1ε(t).

It follows that

L-1-γ1(sα1-γ1)(γ2sα1-γ1sα2)=y1(t),

and

L-1-γ2(sα2-γ2)(γ1sα2-γ2sα1)=y2(t).

Therefore the solution y(t) of system (9) is

y(t)=y1(t)+y2(t).

Example 4

Consider the transfer function

H(s)=sα3-2(sα1-i)(sα2+i), (10)

where i=-1. We want the impulse response for the particular case in which α1=α2. Applying (5) to transfer function (10), we get that

sα3-2(sα1-i)(sα2+i)=isα3(isα1+isα2)(sα1-i)+isα3(isα2+isα1)(sα2+i)-2sα1(isα2+isα1)(sα1-i)+2sα2(isα1+isα2)(sα2+i)=isα3-2sα1(isα1+isα2)(sα1-i)+isα3+2sα2(isα2+isα1)(sα2+i).

Because α1=α2, then

sα3-2(sα1-i)(sα1+i)=-i(sα1+i)+i(sα1-i)+1/2sα3sα1(sα1+i)+1/2sα3sα1(sα1-i).

Following the methodology used in the previous examples, we obtain that the solution y(t) of system (10) is given by

y(t)=2k=1(-1)kt2kα1-1Γ((2kα1)ε(t)+k=1(-1)k+1t2kα1-α3-1Γ(2kα1-α3)ε(t),

which is a real solution.

Integer/fractional inversion of each partial fraction

The solution supplied by the approach presented above does not show the underlying structure of a TF. This limitation is revealed when we try to compute its inversion by using the Bromwich integral for inverting the LT. We start by fixing a branch cut line on the left complex half-plane, since the TF must be analytic on the right half plane. Let us choose the left half real axis for the cut and assume that each term of the TF is continuous from above on the branch cut line. As seen, it verifies limsH(s)=0,|arg(s)|<π. We will assume that lims0sH(s)=0 so that there is a finite initial value [3], [11].

Consider (6) where we illustrate a general decomposition of a TF with two pseudo-zeroes. As seen the decomposition involves terms having the form:

F(s)=sβ(sαi-γi)j=1jin(γjsαi-γisαj), (11)

where β is such that limsF(s)=0,|arg(s)|<π, and lims0sF(s)=0.

Remark 4

  • We remember that a given pseudo-pole p, corresponding to an order a, is a pole, if when s=|s|eiθ and p=|p|eiϕ, we have |s|=|p|1/a and θ=ϕ/a. However, we have -π<θπ and, therefore, we only obtain a pole if -aπ<ϕaπ.

  • The term G(s)=j=1jin(γjsαi-γisαj) in (11) is analytic in the first Riemann surface and has no zeroes (of course in the analyticity region that excludes the origin that is the branch cut point).

In these conditions we can use the integration path C in Fig. 1, [3], [10], and we apply the residue theorem. Let uR+ and consider F(eiπu) and F(e-iπu), the values of F(s) immediately above and below the branch cut line. Proceeding as in [3] we obtain

f(t)=Aieγi1/αitε(t)+12πi0F(e-iπu)-F(eiπu)e-utdu·ε(t), (12)

where the constant Ai is the residue of (11) at γi1/αi:

Ai=γiβαiαiγi1/αi-1j=1jin(γjγi-γiαjαi+1).

Computing the LT of both sides in (12) we obtain

F(s)=Fi(s)+Ff(s),

where the integer order part is

Fi(s)=Ais-γi1/αi,Re(s)>max(Re(γi1/αi)),

and the fractional part is

Ff(s)=12πi0F(e-iπu)-F(eiπu)1s+udu, (13)

valid for Re(s)>0.

Fig. 1.

Fig. 1

Integration path.

The above steps led us to realize that:

  • For αi=1, we have no fractional component.

  • For αi<1, we may have two components depending on the location of γi in the complex plane
    • If |arg(γi)|>παi, then we do not have the integer order component; it is a purely fractional system.
    • If |arg(γi)|παi, then it is mixed character system in the sense that we have both components.
    • When |arg(γi)|=π2αi, the integer order component is sinusoidal; however, the fractional component exists also.
  • The stability condition comes only from the integer order component. In fact, and as it is straightforward to verify, the integer order component is stable if π2αi<|arg(γi)|<παi, and unstable if |arg(γi)|<π2αi. The case |arg(γi)|=π2αi corresponds to a critically stable system.

  • Concerning to the fractional part we can verify that F(e-iπu)-F(eiπu), is a bounded function. Therefore, the integral in (13) is also bounded and decreases to zero as t goes to infinite, but slowly.

Applying the above considerations to the general system (1) we are led to conclude that we can decompose it in two parcells with integer and fractional behaviors, namely:

  • Integer term: it has an impulse responses corresponding to linear combinations of exponentials that, in the stable case, go to zero very fast.

  • Fractional term: they are long memory systems that exist always even there are no poles as when arguments of the pseudo-polynomial roots have absolute values greater than πα, where α is the corresponding derivative order smaller then 1.

Example 5

Consider the basic element

F(s)=s0.2(s1/2-γ1)((-2+i)s1/2+γ1s0.51).

The Fig. 2, Fig. 3, Fig. 4, Fig. 5 illustrate the behaviour of the integer and fractional solutions for poles in both sides of the stability threshold: arg(γ1)=0.71π2 and arg(γ1)=0.69π2, with |γ1|=1.

Fig. 2.

Fig. 2

Integer part arg(γ1)=0.69π2.

Fig. 3.

Fig. 3

Integer part arg(γ1)=0.71π2.

Fig. 4.

Fig. 4

Fractional part arg(γ1)=0.69π2.

Fig. 5.

Fig. 5

Fractional part arg(γ1)=0.71π2.

As expected, the fractional part does not change its behaviour: it is always stable. This is in agreement with the results in [11]. The instability and oscillation comes from the integer part.

Theorem 5

The result stated in (13) can be generalized for any TF as in (1). Let Γp=γj:-παj<arg(γj)παj,j=1,2,, be the set of the poles of the TF (of course, subset of the pseudo-poles). Then

h(t)=γiΓpAieγi1/αitε(t)+12πi0H(e-iπu)-H(eiπu)e-utdu·ε(t).

The proof is not very difficult to obtain from the above results (see [3]).

In Fig. 6 we depict the fractional parts of the response of the system in Example 2 and another one resulting from it with the substitutions +1 for -1 and +2 for -2. As seen, the behaviour is similar, at least for large values of t.

Fig. 6.

Fig. 6

Fractional parts of the impulse responses of systems H(s)=sα3(sα1±1)(sα2±2).

Conclusions

In this paper a study of non-commensurate fractional linear systems was done proposing a methodology similar to the one followed in the commensurate case. For it a partial fraction decomposition was obtained using a recursive procedure. Each partial fraction was inverted in two different ways: a Mittag–Leffler like procedure and a integer/fractional decomposition. Some examples were presented to illustrate the proposed approach.

Declaration of Competing Interest

The authors have declared no conflict of interest.

Compliance with Ethics Requirements

This article does not contain any studies with human or animal subjects.

Acknowledgments

This work was funded by Portuguese National Funds through the FCT – Foundation for Science and Technology under the project UIDB/00066/2020. The second author was supported by Autonomous University of Mexico City (UACM) under the project PI-CCyT-2019-15.

Footnotes

Peer review under responsibility of Cairo University.

Contributor Information

Manuel D. Ortigueira, Email: mdo@fct.unl.pt.

Gabriel Bengochea, Email: gabriel.bengochea@uacm.edu.mx.

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