Table 1.

The VUE RCTs: two parallel RCTs evaluating the surgical options for upper compartment pelvic organ prolapse

The VUE RCTs [9, 10]	Design and comparisons	Condition	No. of participants recruited at the time of suspension	Mesh in use within the trial	Implications of suspension
Uterine trial	Vaginal hysterectomy compared to uterine suspension	Uterine prolapse	224	Uterine suspension procedure dependant on the surgeon’s normal practice (as such, patients may have no mesh, abdominal mesh* or transvaginal mesh)	Recruitment Temporary suspension in Scottish sites only (suspending recruitment of new participants and randomisation of consented participants). No change to the rest of the UK. Intervention Sites advised to follow local NHS governance on the use of TV synthetic mesh for participants awaiting surgery. This may have deviated from the randomised intervention. Follow-up Continued as per protocol
Vault trial	Abdominal vault suspension compared to a vaginal vault suspension	Vault prolapse	87	Abdominal procedure requires the use of abdominal mesh*; vaginal vault procedure dependant on the surgeon’s normal practice (as such, patients may have no mesh or may have transvaginal mesh)

*Abdominal mesh was not included in the requested suspension