Table 6.

A summary of literature pertaining to various immune functions demonstrated for the lectins naturally occurring in human blood (plasma/serum).

S. No.	Immune function	Action	References
1. C-Reactive protein
1.	Phagocytic response of macrophages	Enhancement	Hokama et al. (1962); Ganrot and Kindmark (1969); Mortensen et al. (1976);
		(= Opsonophagocytosis)	Mortensen and Duskiewiez (1977); Zahedi et al. (1989); Culley et al. (1996)
2.	Phagocytic response of neutrophils	Enhancement	Kindmark (1971); Kilpatrick and Volanakis (1985); Kilpatrick et al. (1987);
		(= Opsonophagocytosis)	Edwards et al. (1982); Richardson et al. (1991); Mold et al. (2001)
3.	Lymphocyte blast transformation	Induction	Hornung and Fritchi (1971)
4.	Inhibition of growth of melanoma cells by	Enhancement	Hornung (1972)
	T-lymphocytes
5.	Complement system	Activation	Kaplan and Volanakis (1974); Siegel et al. (1975); Claus et al. (1977);
			Volanakis (1982); Jiang et al. (1992); Gewurz et al. (1995);
			Wolbink et al. (1996); Szalai et al. (1999)
6.	Response of T lymphocytes to allogeneic cells	Inhibition	Mortensen et a1., 1975
7.	Antitumour activity of macrophages	Induction	Deodhar et al. (1982); Zahedi and Mortensen (1986);
			Zahedi et al. (1989); Tebo and Mortensen (1991)
8.	Colony formation of B lymphocytes	Modulation	Whisler et al. (1986)
9.	Complement activation by alternative pathway	Inhibition	Mold and Gewurz (1981); Mold et al. (1984)
10.	Respiratory burst in peripheral blood monocytes	Enhancement	Zeller et al. (1986)
11.	Migration of peritoneal macrophages	Inhibition	Miyagawa et al. (1989)
12.	Superoxide production and granule secretion by neutrophils	Inhibition	Buchta et al. (1988); Dobrinich and Spagnuolo (1991)
13.	Neutrophil chemotaxis	Inhibition	Kew et al. (2000); Zhong et al. (1998)
14.	Production of hydrogen peroxide by neutrophils	Induction	Tebo and Mortensen (1991)
15.	Production of pro - inflammatory cytokines from alveolar macrophages	Stimulation	Rochemonteix et al. (1993)
16.	MBL - initiated complement - mediated cytolysis	Inhibition	Suankratay et al. (1998)
17.	Complement activation by alternative pathway	Regulation	Mold et al. (1999)
2. Serum amyloid protein
1.	C3b/C3bi - mediated phagocytosis by monocytes	Enhancement	Wright et al. (1983)
2.	Complement system	Activation	Bristow and Boackle (1986); Ying et al. (1993); Emsley et al. (1994)
3.	Factor I - mediated inactivation of C4b	Prevention	Schwalbe et al. (1992); Frutos et al. (1995)
3. Mannan-binding lectin
1.	Phagocytic response of neutrophils	Enhancement	Miller et al. (1968); Soothill and Harvey (1976); Kuhlman et al. (1989);
		(= Opsonophagocytosis)	Malhotra et al. (1994); Turner (1996); Holmskov et al. (2003)
2.	Complement system	Activation	Ikeda. et al., 1987a, Ikeda et al., 1987b; Lu et al. (1990); Yakota et al. (1995);
			Neth et al. (2002); Fujita et al. (2004)
3.	Phagocytic response of macrophages	Enhancement	Kuhlman et al. (1989); Turner (1996); Fraser et al. (1998);
		(= Opsonophagocytosis)	Tenner (1999); Kilpatrick (2002); Holmskov et al. (2003)
4.	Infection by human immunodeficiency virus	Inhibition	Ezekowitz et al. (1989)
5.	Neutrophil response against influenza A virus	Activation	Hartshorn et al. (1993); Malhotra et al. (1994)
6.	Complement - dependent cytotoxicity	Promotion	Ohta and Kawasaki (1994)
7.	Antitumour activity	Expression	Muto et al. (1999); Ma et al. (1999)
8.	Complement - independent cytotoxicity	Promotion	Ma et al. (1999)
9.	Neutralization of influenza A virus	Promotion	Anders et al. (1994); Kase et al. (1999)
10.	Release of cytokines by monocytes	Regulation	Jack et al. (2001)
11.	Phagocytic uptake of apoptotic cells by macrophages	Initiation	Ogden et al. (2001)
12.	Inflammatory reactions and immunity	Modulation	Turner (2003); Terai et al. (1997)
4. H - Ficolin
1.	Complement system	Activation	Matsushita and Fujita. (2001); Matsushita et al. (2002); Lu et al. (2002)
2.	Growth of Aerococcus viridians	Inhibition	Tsujimura et al. (2001)
5. L - Ficolin
1.	Phagocytic response	Enhancement	Matsushita et al. (1996); Lu et al. (2002)
	of neutrophils	(= Opsonophagocytosis)
2.	Complement system	Activation	Matsushita et al. (2000); Matsushita and Fujita (2001); Matsushita et al. (2002)
			Lu et al. (2002); Lynch et al. (2004)