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. 2007 Jul;4(3):460–484. doi: 10.1016/j.nurt.2007.05.004

Magnetic resonance imaging of myelin

Cornelia Laule 1,✉, Irene M Vavasour 1, Shannon H Kolind 2, David K B Li 1, Tony L Traboulsee 3, G R Wayne Moore 4, Alex L MacKay 1
PMCID: PMC7479725  PMID: 17599712

Summary

The ability to measure myelin in vivo has great consequences for furthering our knowledge of normal development, as well as for understanding a wide range of neurological disorders. The following review summarizes the current state of myelin imaging using MR. We consider five MR techniques that have been used to study myelin: 1) conventional MR, 2) MR spectroscopy, 3) diffusion, 4) magnetization transfer, and 5) T2 relaxation. Fundamental studies involving peripheral nerve and MR/histology comparisons have aided in the interpretation and validation of MR data. We highlight a number of important findings related to myelin development, damage, and repair, and we conclude with a critical summary of the current techniques available and their potential to image myelin in vivo.

Key Words: Myelin, MR, histologic validation, T2, diffusion, magnetization transfer, MR spectroscopy

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