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. Author manuscript; available in PMC: 2020 Sep 9.
Published in final edited form as: Cell. 2019 Jun 27;178(3):672–685.e12. doi: 10.1016/j.cell.2019.05.048

Figure 1. Whole-Brain Fos Mapping Identifies Heat-Sensitive Neurons.

Figure 1.

(A) Schema for whole-brain activity mapping in response to thermal challenge.

(B) Whole-brain imaging and ClearMap results for the POA (top), hypothalamus (middle), and DRN (bottom). p values maps display differentially activated brain loci in 38°C versus RT (n = 5 mice per group).

(C) Vgat and Fos colocalization after 38°C thermal challenge. Significantly increased Fos and Vgat colocalization was observed at 38°C, compared to room temperature (p < 0.0001). Unpaired t test comparing treatments (n = 3 mice per group). White arrows designate double-labeled cells.

Scale bar, 100 mm. Data are presented as mean ± SEM.

See also Figure S1 and Table S1.