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. 2020 Aug 21;10(23):10531–10547. doi: 10.7150/thno.40944

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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Alterations of alternative polyadenylation (APA) events in clinically actionable therapeutic targets in triple-negative breast cancer (TNBC). (A) Gene Set Enrichment Analysis (GSEA) of four APA subtypes (LAR, MLIA, BL and S). (B) Distribution of the interquartile range (IQR) of the short 3′UTR index (SUI) of clinically actionable genes across APA subtypes. (C) Distribution of the IQR of the SUI of clinically actionable genes across Lehmann subtypes. Abbreviations: APA, alternative polyadenylation; BL, basal-like; FDR, false discovery rate; GSEA, Gene Set Enrichment Analysis; IQR, interquartile range; LAR, luminal androgen receptor; MLIA, mesenchymal-like immune-activated; NES, normalized enrichment score; S, suppressed; SUI, short 3′UTR index; TNBC, triple-negative breast cancer.