Fig. 4. Cell line correlation rankings are largely reproducible across RNA-seq datasets from different laboratories.

a We performed our correlation rankings using RNA-seq data from 25 MM cell lines available in both the CCLE and Keats lab databases, with each line compared with all patients in CoMMpass. Cell lines at the top of the ranking (blue) tend to remain at the top in both rankings, and those at the bottom (red) tend to remain at the bottom in both rankings. b Further supporting reproducibility, numerical rankings in CCLE and relative rankings in Keats database (numbered 1–25 to reflect rank order in overall 66 cell line ranking) are highly correlated. c Similarly, mean Spearman R of transcriptome between each cell line and all patients, as determined from each database, is highly consistent. Linear regression displayed with 95% confidence intervals.